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Citation: GE Yu-Hua, WU Ya-Ming, XUE Zhong-Jun. Synthesis of 6-Cyanoindole-3-carboxaldehyde[J]. Chinese Journal of Applied Chemistry, ;2005, 22(4): 454-456. shu

Synthesis of 6-Cyanoindole-3-carboxaldehyde

1.
Department of Chemistry & Chemical Engineering, Southeast University, Nanjing 210096

Corresponding author: GE Yu-Hua,
Received Date: 28 June 2004
Available Online: 28 October 2004

Intermediate 6-cyanoindole was obtained from 4-methylbenzonitrile as a raw material via nitration with the mixed acid,condensation with N,N-dimethylformamide dimethyl acetal and cyclic reaction with Raney nickel-hydrazine.6-Cyanoindole-3-carboxyaldehyde was synthesized via the Vilsmeier reaction of 6-(cyanoindole) with N,N-diemthylformamide and phosphorus oxychloride.The structure of the target compound was confirmed by ¹H NMR,IR and elemental analysis.The total yield was 57% and the purity of the final product reached 99.4%.
- cyanoindole,
- cyanoindolecarboxaldehyde,
- synthesis
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