Citation:
SUO Zhi-Rong, ZHANG Zun-Ting, ZHENG Jian-Bin. Preparation of Natrium Sulfogenisteinates and Their Anti Peroxidation Activity for Lipids[J]. Chinese Journal of Applied Chemistry,
;2005, 22(10): 1083-1086.
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Genistein(G) has the effects of anti-tumour and anti-arteriosclerosis.It can also reduce plasma lipid and kill various cancer cells without damaging the normal cells.Nevertheless,its medical application is much restricted because of its poor solubility in water and fat.In this study,its two new water-soluble derivatives,genistein-3'-sodium sulfonate(G1) and genistein-3',6-disodium sulfonate(G2),were prepared via sulfation and column chromatography separation.The structures of the two compounds were identified by means of IR and 1H NMR.At the same time,the inhibitory ratios of G,G1 and G2 against lipid peroxidation were determined.The results show that G1 and G2 not only have stronger anti-peroxidation activity for lipids than G,but also have good water solubilities.
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Keywords:
- genistein,
- natrium sulfogenisteinate,
- water-soluble,
- anti-peroxidation
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