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Citation: WEI Jia, TIAN Man-Man, SHI De-Qing. Synthesis of N¹-(2-furanidyl)-N³-Alkylthioalkyl-5-Fluorouracil and its Oxidized Products[J]. Chinese Journal of Applied Chemistry, ;2006, 23(6): 655-658. shu

Synthesis of N¹-(2-furanidyl)-N³-Alkylthioalkyl-5-Fluorouracil and its Oxidized Products

1.
Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Center China Normal University, Wuhan 430079

Corresponding author: SHI De-Qing,
Received Date: 8 September 2005
Available Online: 18 December 2005
Fund Project: 武汉市青年科技晨光计划(20025001024) (20025001024)教育部科学技术研究重点项目(02140)资助项目 (02140)

Nine N¹-furanidin-2'-yl-N³-alkylsulphonylalkyl-5-fluorouracils were synthesized via the oxidations of N¹-furanidin-2'-yl-N³-alkylthioalkyl-5-fluorouracils 2.The intermediates 2 were prepared by the reactions of N¹-furanidin-2'-yl-N³-bromoalkyl-5-fluorouracil 1 with sodium alkylsulfide.The structures of the products were confirmed by means of ¹H NMR,IR,MS and elemental analysis.The inhibitory activities of compounds 3 to A549,HCT-8 and Bel-7402 cancer cells were tested in vitro.
- fluorouracil,
- sulfone,
- antitumor drug
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Synthesis of N1-(2-furanidyl)-N3-Alkylthioalkyl-5-Fluorouracil and its Oxidized Products

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通讯作者: 陈斌, bchen63@163.com

Synthesis of N¹-(2-furanidyl)-N³-Alkylthioalkyl-5-Fluorouracil and its Oxidized Products