Home

Citation: LIN You-Wen, HUANG Zun-Xin, LUO Hong-Bing. Synthesis and Characterization of N-(4-Hydroxy-3mehtoxybenzyl) chitosan and pH Sensitivity of Its Hydrogel[J]. Chinese Journal of Applied Chemistry, ;2006, 23(7): 770-775. shu

Synthesis and Characterization of N-(4-Hydroxy-3mehtoxybenzyl) chitosan and pH Sensitivity of Its Hydrogel

1.
a College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002;
2.
b School of Pharmaceutical, Fujian Medical University, Fuzhou

Corresponding author: HUANG Zun-Xin,
Received Date: 30 July 2005
Available Online: 24 December 2005
Fund Project: 福建省自然科学基金计划资助项目(C0310024) (C0310024)福建省教育厅科研经费资助项目(K04056) (K04056)

By the reaction of chitosan with vanillin,Schiff's base was firstly obtained,followed by the eaction of NaBH₄ with Schiff's base to yield water-soluble N-(4-hydroxy-3-mehtoxybenzyl) chitosan (VCS).The chemical structure of the modified chitosan VCS was characterized by FTIR,¹H NMR and UV spectroscopies.Degree of substitution of N-4-hydroxy-3-mehtoxybenzyl determined with colloid titration was 2.37 mmol/g.The swelling characteristics of hydrogels(VCSG) prepared by cross-linking of glutaraldehyde with VCS were studied.The results showed that the swelling ratio(SR) of VCSG was decreased with the increasing of the dosage of glutaraldehyde.The swelling ratios of VCSG with different cross-linking degrees were decreased with the increasing of the pH value of the buffer solution between 1.2 to 7.4.The swelling ratios of VCSG were increased with the increasing of the pH value of the buffer solution between 9.0 to 11.0.The VCSG with a lower cross-linking degree swelled more significantly in a pH=1.2 buffer solution than in other medium,the VCSG with a high cross-linking degree swelled similarly and lower SR in buffer solution with different pH values.VCSG showed pH-sensitive in buffer solutions.The release behavior of famotidine entrapped in the hydrogel showed different speeds with the change of the pH value of medium in vitro.The release speeds of famotidine in VCSG in the media of pH=1.2 and 3.0 were much faster than those in the media of pH=5.0 and 7.4,both showed slow release effect.VCSG is pH sensitive and the swelling behavior of VCSG can be regulated by changing the dosage of the cross-linking agent,and has the potential as being the carrier for controlling drug release.
- chitosan,
- modification,
- pH-sensitivity,
- hydrogel,
- swelling ratio,
- drug release
1. [1]
  Dong-Bing Cheng , Junxin Duan , Haiyu Gao . Experimental Teaching Design on Chitosan Extraction and Preparation of Antibacterial Gel. University Chemistry, 2024, 39(2): 330-339. doi: 10.3866/PKU.DXHX202308053
2. [2]
  Xiaonan Liu , Zhi Lei , Maoxia Lu , Dongwei Ma , Chuan Wang , Zehong Wu , Daohai Zhang . Construction of Fe₃O₄@ZIF-67 based flexible multifunctional hydrogels for electromagnetic interference shielding and strain sensing. Acta Physico-Chimica Sinica, 2026, 42(10): 100354-0. doi: 10.1016/j.actphy.2026.100354
3. [3]
  Qiang Zhou , Pingping Zhu , Wei Shao , Wanqun Hu , Xuan Lei , Haiyang Yang . Innovative Experimental Teaching Design for 3D Printing High-Strength Hydrogel Experiments. University Chemistry, 2024, 39(6): 264-270. doi: 10.3866/PKU.DXHX202310064
4. [4]
  Qingyang Cui , Feng Yu , Zirun Wang , Bangkun Jin , Wanqun Hu , Wan Li . From Jelly to Soft Matter: Preparation and Properties-Exploring of Different Kinds of Hydrogels. University Chemistry, 2024, 39(9): 338-348. doi: 10.3866/PKU.DXHX202309046
5. [5]
  Xiaosong PU , Hangkai WU , Taohong LI , Huijuan LI , Shouqing LIU , Yuanbo HUANG , Xuemei LI . Adsorption performance and removal mechanism of Cd(Ⅱ) in water by magnesium modified carbon foam. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1537-1548. doi: 10.11862/CJIC.20240030
6. [6]
  Xuejiao Wang , Suiying Dong , Kezhen Qi , Vadim Popkov , Xianglin Xiang . Photocatalytic CO₂ Reduction by Modified g-C₃N₄. Acta Physico-Chimica Sinica, 2024, 40(12): 2408005-0. doi: 10.3866/PKU.WHXB202408005
7. [7]
  Ziyi Xue , Xuemeng Li , Minru Liu , Qing Yang , Gang Xie . 蟹壳家族变形记. University Chemistry, 2026, 41(9): 222-228. doi: 10.12461/PKU.DXHX202507010
8. [8]
  Yu Liu , Pengfei Li , Yize Liu , Zaicheng Sun . Recent advances in carbon dots as a single photocatalyst. Acta Physico-Chimica Sinica, 2026, 42(2): 100167-0. doi: 10.1016/j.actphy.2025.100167
9. [9]
  Songmei Ma , Ying Zhang , Gang Liu , Wenlong Xu . Comprehensive Experiment Teaching Exploration and Practice in Polymeric Materials Integrating Research-Driven Learning, Creativity-Enhanced Competency, and Science-Education Synergy: A Case Study of Machine Learning-Assisted Intelligent Handwriting Recognition System. University Chemistry, 2026, 41(1): 289-297. doi: 10.12461/PKU.DXHX202509083
10. [10]
  Ziyao Liu , Xiaoli Ji , Wenwen Fu , Minhao Tang , Qian Zhao , Yahan Yang , Ying Ma , Hongguang Li . Surfactant-mediated sol preparation: an innovative design and teaching practice in physical chemistry experiments. University Chemistry, 2026, 41(6): 343-352. doi: 10.12461/PKU.DXHX202504006
11. [11]
  Zhongrui Wang , Yuwen Meng , Xu Wang . 双层水凝胶的制备及其pH响应变形实验. University Chemistry, 2025, 40(8): 255-264. doi: 10.12461/PKU.DXHX202410038
12. [12]
  Yuena Yang , Xufang Hu , Yushan Liu , Yaya Kuang , Jian Ling , Qiue Cao , Chuanhua Zhou . The Realm of Smart Hydrogels. University Chemistry, 2024, 39(5): 172-183. doi: 10.3866/PKU.DXHX202310125
13. [13]
  Junhan Zhang , Yunbo Lei , Xiaoyu He , Lingxiang Gao . 智能水凝胶未来博物馆参观记. University Chemistry, 2026, 41(8): 227-234. doi: 10.12461/PKU.DXHX202507007
14. [14]
  Wenjun Yang , Qiaoling Tan , Wenjiao Xie , Xiaoyu Pan , Youyong Yuan . Construction and Characterization of Calcium Alginate Microparticle Drug Delivery System: A Novel Design and Teaching Practice in Polymer Experiments. University Chemistry, 2025, 40(3): 371-380. doi: 10.12461/PKU.DXHX202405150
15. [15]
  Tengjiao Wang , Tian Cheng , Rongjun Liu , Zeyi Wang , Yuxuan Qiao , An Wang , Peng Li . Conductive Hydrogel-based Flexible Electronic System: Innovative Experimental Design in Flexible Electronics. University Chemistry, 2024, 39(4): 286-295. doi: 10.3866/PKU.DXHX202309094
16. [16]
  Zhaoxuan ZHU , Lixin WANG , Xiaoning TANG , Long LI , Yan SHI , Jiaojing SHAO . Application of poly(vinyl alcohol) conductive hydrogel electrolytes in zinc ion batteries. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 893-902. doi: 10.11862/CJIC.20240368
17. [17]
  Ke Qiu , Fengmei Wang , Mochou Liao , Kerun Zhu , Jiawei Chen , Wei Zhang , Yongyao Xia , Xiaoli Dong , Fei Wang . A Fumed SiO₂-based Composite Hydrogel Polymer Electrolyte for Near-Neutral Zinc-Air Batteries. Acta Physico-Chimica Sinica, 2024, 40(3): 2304036-0. doi: 10.3866/PKU.WHXB202304036
18. [18]
  Ziwen Lei , Mingyin Liu , Jiayi Shi , Yahan Shan , Qi Zhang . 当超分子二肽遇上酸碱指示剂：热响应水凝胶的智能可视化. University Chemistry, 2026, 41(8): 210-219. doi: 10.12461/PKU.DXHX202508014
19. [19]
  Hongyun Liu , Jiarun Li , Xinyi Li , Zhe Liu , Jiaxuan Li , Cong Xiao . Course Ideological and Political Design of a Comprehensive Chemistry Experiment: Constructing a Visual Molecular Logic System Based on Intelligent Hydrogel Film Electrodes. University Chemistry, 2024, 39(2): 227-233. doi: 10.3866/PKU.DXHX202309070
20. [20]
  Lijuan Liu , Xionglei Wang . Preparation of Hydrogels from Waste Thermosetting Unsaturated Polyester Resin by Controllable Catalytic Degradation: A Comprehensive Chemical Experiment. University Chemistry, 2024, 39(11): 313-318. doi: 10.12461/PKU.DXHX202403060

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(1040)
HTML views(104)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return