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Citation: WANG Cai-Ping, LU Hai-Feng, ZHANG Hong-Lin, KANG Ge-Li. Drug Resistance of E. coli to Tetrandrine and Alkaloids of Stephenia tetrandra S. Moore by Microcalorimetry[J]. Chinese Journal of Applied Chemistry, ;2006, 23(8): 942-944. shu

Drug Resistance of E. coli to Tetrandrine and Alkaloids of Stephenia tetrandra S. Moore by Microcalorimetry

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a College of Chemistry Science, Qufu Normal University, Qufu 273165;
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b Department of Chemistry, Tongji University, Shanghai;
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c Department of Chemial Engineering, Zibo Vocational College, Zibo

Corresponding author: ZHANG Hong-Lin,
Received Date: 18 October 2005
Available Online: 26 March 2006

Tetrandrine(Tet) and alkaloids of Stephenia tetrandra S. Moore(AST) were isolated from Chinese natural medicine of Stephenia tetrandra S. Moore.The inhibitory action of Tet and AST and the drug resistance of E. coli to Tet and AST were studied by microcalorimetric method.It was found that Tet and AST had inhibitory action on E. coli and the inhibitory action of Tet was better than that of AST.But the drug resistance of E. coli to AST was more slowly induced than that of Tet,which may be because the complicated components in AST could have a synergetic effect on inhibiting drug resistance.
- Tetrandrine,
- Stephenia tetrandra S. Moore,
- alkaloid,
- drug resistance,
- E. coli
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