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Citation: JIA Li-Hua, ZENG Xiao-Dan, GUO Xiang-Feng, WANG Qing-Bin. Interaction Between Enrofloxacin and Bovine Serum Albumin[J]. Chinese Journal of Applied Chemistry, ;2006, 23(9): 957-960. shu

Interaction Between Enrofloxacin and Bovine Serum Albumin

1.
Chemical and Chemistry Engineering College of Qiqihar University, Qiqihaer 161006

Corresponding author: JIA Li-Hua,
Received Date: 31 October 2005
Available Online: 6 January 2006
Fund Project: 黑龙江省自然科学基金项目(B0202,E200530) (B0202,E200530)

The binding reaction between enrofloxacin(EFLX) and bovine serum albumin(BSA) in an aqueous solution of methanol was studied by means of fluorescence and UV-Vis.The results indicate that the association constant(K_A) is 4.16×10⁵ L/mol,and they reacted in a molar ratio of 1:1 with a binding distance r=4.40 nm.The Stern-Volmer curve illustrates that the combination reaction of EFLX and BSA is a static quenching process.
- enrofloxacin,
- bovine serum albumin,
- fluorescence quenching
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