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Citation: XUE Yun-Ning, LIU Guo-Hua, XUE Si-Jia. Synthesis and Herbicidal Activity of N-(4,6-disubstituted pyrimidin-2-yl)-2-(2,4-dichlorophenoxy) propionamide[J]. Chinese Journal of Applied Chemistry, ;2006, 23(11): 1200-1203. shu

Synthesis and Herbicidal Activity of N-(4,6-disubstituted pyrimidin-2-yl)-2-(2,4-dichlorophenoxy) propionamide

1.
Department of Chemistry, College of Life and Environment Science, Shanghai Normal University, Shanghai 200234

Corresponding author: LIU Guo-Hua,
Received Date: 22 November 2005
Available Online: 16 January 2006
Fund Project: 国家自然科学基金资助(20543007) (20543007)上海市重点学科建设项目资助项目(T0402) (T0402)上海市教育委员会科学研究项目(05D215) (05D215)

Seven novel N-(4,6-disubstitutedpyrimidin-2-yl)-2-(2,4-dichlorophenoxy) propionamides were synthesized through coupling of 2,4-dichlorophenoxypropionyl chloride with 4,6-disubstituted-2-amino-pyrimidine.All these compounds were characterized by ¹H NMR,IR,MS and elemental analysis.The preliminary herbicidal tests showed that most of the compounds possessed inhibitory activity against selected weeds in a concentration of 100 mg/L.Among these compounds,6c exhibited 70%,85%,95% inhibitory rates against root growth of Echinochloa crusgallis L.,Sorghum bicolort,Digitaria sanguinalis(L.) scop(monocotyledon plant),and 98%,80%,80% inhibitory rates against root growth of Amaranthus retroflexus L.,Cucumis Sativus L.,Brassica campestris L.(dicotyledon plant).The title compounds also showed selective inhibitory activities against root and stalk growth for monocotyledon plant.In addition,95% inhibitory rate was observed for compound 6c against root and stalk growth of Amaranthus retroflexus L.and Digitaria sanguinalis(L.) Scop. and for compound 6f against root and stalk growth of Amaranthus retroflexus L. indicating their potential as candidates for herbicide application.
- dichlorophenoxypropionic acid,
- pyrimidine,
- amide,
- synthesis,
- herbicidal activity
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