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Citation: KONG Xue, GAO Yong-Chao, CHEN Guan-Hong, WANG Jia-Ning, QIU Wei-Zhong, CHI Jian-Guo. Improvement on Synthesis Method of Antibiotic 2,4-Diacetylphloroglucinol[J]. Chinese Journal of Applied Chemistry, ;2007, 24(4): 471-473. shu

Improvement on Synthesis Method of Antibiotic 2,4-Diacetylphloroglucinol

1.
Biology Institute, Shandong Academy of Sciences, Ji'nan 250014

Corresponding author: KONG Xue,
Received Date: 22 May 2006
Available Online: 30 November 2006
Fund Project: 国家"十五"科技攻关计划资助课题(2004BA308A22-13) (2004BA308A22-13)

2,4-Diacetylphloroglucinol(DAPG) was synthesized via the Friedel-Crafts reaction of phloro-glucinol and acetic anhydride with BF₃ as the catalyst and ether as the solvent.The product was purified by silicon gel column chromatography.The structure of DAPG was characterized by ¹H NMR and MS.The reaction conditions,such as the ratio of reactants,reaction temperature and reaction time were investigated.The optimal reaction conditions were the molar ratio of phloroglucinol:acetic anhydride:BF₃ being 1:2.1:5.5,reaction temperature 26~30℃ and reaction time 24 h,and the yield was 62.0%.
- phloroglucinol,
- diacetylphloroglucinol(DAPG),
- synthesis,
- acetylation
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