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Citation: WU Xiang-Long, HAN Jie, HE Huai-Zhen, SHI Zhen. A Novel Synthetic Method for 1-Cyclopropylethanone[J]. Chinese Journal of Applied Chemistry, ;2007, 24(9): 1077-1079. shu

A Novel Synthetic Method for 1-Cyclopropylethanone

1.
Department of Chemistry, Northwest University, Xi'an 710069

Corresponding author: SHI Zhen,
Received Date: 29 September 2006
Available Online: 12 February 2007
Fund Project: 国家自然科学基金(20472067) (20472067)高等学校博士学科点专项科研基金(20050697003) (20050697003)

2-Cyclopropylbenzimidazole was synthesized from o-phenylenediamine and cyclopropanecarboxylic acid with polyphosphoric acid as the catalyst under microwave. An unreported compound 2-cyclopropylbenzimidazolium salt was obtained from 2-cyclopropyl benzimidazole and iodomethane. 1-Cyclopropylethanone was prepared via the addition-hydrolysis reaction of the 2-cyclopropyl benzimidazolium salt with a Grignard reagent. It was characterized by means of elemental analysis, IR, MS and ¹H NMR. The title compound is colorless oil. The yield was 67%.This synthetic method for preparation of 1-cyclopropylethanone has not been reported.
- benzimidazolium salt,
- Grignard reagent,
- cyclopropylethanone,
- synthesis
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