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Citation: LI Guo-Ming, YE Jun-Sheng, ZHENG Guo-Hong, LIU Cong, WANG Chao-Yang. Preparation of Levodopa-Chitosan Microspheres and The Drug-Release Performance[J]. Chinese Journal of Applied Chemistry, ;2007, 24(9): 1062-1065. shu

Preparation of Levodopa-Chitosan Microspheres and The Drug-Release Performance

1.
School of Chemistry and Environment, South China Normal University, GuangZhou 510006

Corresponding author: LI Guo-Ming,
Received Date: 8 September 2006
Available Online: 8 February 2007

With sodium tripolyphosphate as ionic crosslinking reagent, levodopa-chitosan microspheres were prepared by means of emulsion-dispersion and ionic cross-linking. The physicochemical properties and the drug-release performance of the microspheres were investigated. The polarized optical microscopy showed that the particles prepared were basically spheric. The average diameter of the microspheres detected by a laser particle analyzer was about 3.5 μm. FT-IR analysis indicated that the protonated amino groups in chitosan combined with tripolyphosphate via electrostatic interactions, and levodopa was enwrapped in chitosan microspheres. DSC and XRD analyses indicated that levodopa crystals existed in the microspheres, while chitosan was amorphous. TG analysis showed that the crystallinity of chitosan was lower when chitosan combined with tripolyphosphate. The drug-release performance of the microspheres was affected by the pH value of the media. In acid media, the release of levodopa slowed down when the concentration of chitosan was higher or when the mass ratio of levodopa to chitosan increased. In basic media, the drug-releasing rate was, on the whole, higher than that in acid media.
- levodopa,
- chitosan,
- microspheres,
- ionic cross-linking
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