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Citation: WANG Ying, LIU Zhao-Jie. Synthesis and Bioactivities of 4-(4-methoxybenzylidene)-1H-imidazolin-5-ones Schiff Bases[J]. Chinese Journal of Applied Chemistry, ;2007, 24(9): 1005-1008. shu

Synthesis and Bioactivities of 4-(4-methoxybenzylidene)-1H-imidazolin-5-ones Schiff Bases

WANG Ying ^a,b ,
LIU Zhao-Jie ^a,,

1.
a College of Chemistry, Central China Normal University, Wuhan 43007;
2.
b Medical Science College, China Three Gorges Universithy, Yichang

Corresponding author: LIU Zhao-Jie,
Received Date: 8 October 2006
Available Online: 15 December 2006
Fund Project: 科技部国家重点科技攻关项目(97-563-02-05) (97-563-02-05)

Eleven new schiff bases of 4-(4-methoxybenzylidene)-1-benzylimino-2-meth-ylthio-1H-imidazolin-5-ones(6) were synthesized by condensation reaction of aryl carbaldehyde and 4-(4-methoxybenzylidene)-1-am-ino-2-(meth-ylthio)-1H-imidazol-5-one(5), which was synthesized by S-alkylation of thioimidazol-inone(4). Thioimidazolinone 4 was obtained by a new tandem aza-Wittig reaction of vinyliminophosphorane, carbon disulfide and hydrazine hadrate. The structures of compounds 6 were confirmed by elemental analysis, ¹H NMR, IR and MS. The preliminary bioassay shows that the compounds 6 exhibit good herbicidal and fungicidal activities. Compounds 6j and 6k exhibit 100% inhibition to the tested five fungus.
- imidazolinone,
- Schiff base,
- tandem aza-Wittig reaction,
- synthesis,
- bioactivity
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