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Citation: CHEN He-Ru, ZOU Xiang-Hui, MA Min-Zhi. Preparation of Cefamezin-Sodium Alginate Microcapsules and Its Antibacterialities[J]. Chinese Journal of Applied Chemistry, ;2007, 24(12): 1354-1358. shu

Preparation of Cefamezin-Sodium Alginate Microcapsules and Its Antibacterialities

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a Department of Chemistry, School of Sciences;
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b Multidisciplinary Research Center, Shantou University, Shantou 515063

Corresponding author: CHEN He-Ru,
Received Date: 8 February 2007
Available Online: 30 April 2007
Fund Project: 国家自然科学基金(30672560)资助项目 (30672560)广东省高等院校自然科学研究重点项目(132112) (132112)

Cefamezin-sodium(CEZ) alginate microcapsules were prepared by emulsifying Cefamezin sodium alginate PBS buffer solution into hexane/Span-85 phase and then single-coacervated by calcium chloride.The in vitro drug-release tests of the microcapsules were studied and the inhibition toward Staphylococcus,Hay Bacillus and Escherichia coli by their extravasates respectively were also performed via pervasion method.The results show that the microcapsules were flaxen clathrate,anomalistic granules with diameters 1~15 μm observed by means of Scan Electronic Microscopy(SEM).The entrapment efficiency and drug loading capacity for CEZ reached(80.42±0.26)% and(35.68±2.03)% respectively.In artificial gastric and intestinal fluid,the cyst wall made of sodium alginate displays palliative effect.Extravasates from the microcapsules show good antibacterial effect on Staphylococcus and Hay Bacillus,but weak effect on Escherichia coli.It is disclosed that the microcapsules made of sodium alginate is a good candidate as clinical sustained delivery system for CEZ.
- microemulsion-single coacervation,
- microcapsules,
- sodium alginate,
- sustained delivery reagent,
- cefamezin
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