Citation:
MING Liang, XI Xia, CHEN Ting-Ting, LIU Jie. Voltammetric Determination of Amlodipine at Multi-wall Carbon Nanotube Modified Electrode[J]. Chinese Journal of Applied Chemistry,
;2008, 25(7): 829-833.
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The electrochemical behavior of amlodipine (AM) at the multi-wall carbon nanotube (MWCNT) modified glassy carbon electrode (GCE) was investigated by cyclic voltammetry (CV),linear sweep volta-mmetry (LSV) and differential pulse voltammetry (DPV).The experimental parameters were optimized,and a direct electroanalytical method for determining AM was developed.The oxidation peak current of AM was enhanced significantly at the MWCNT modified GCE,in contrast to that at the bare GCE.Under the optimized experimental conditions,the oxidation peak current varied linearly with the concentration of AM over a range from 1.0×10-7 to 7.5×10-5 mol/L with a detection limit of 4.0×10-8 mol/L.The relative standard deviation (RSD) for 1.0×10-5 mol/L AM was approximately 4.2% (n=10).AM in pharmaceutical formulations was determined by method.
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