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Citation: MING Liang, XI Xia, CHEN Ting-Ting, LIU Jie. Voltammetric Determination of Amlodipine at Multi-wall Carbon Nanotube Modified Electrode[J]. Chinese Journal of Applied Chemistry, ;2008, 25(7): 829-833. shu

Voltammetric Determination of Amlodipine at Multi-wall Carbon Nanotube Modified Electrode

MING Liang ^a ,
XI Xia ^a ,
CHEN Ting-Ting ^a ,
LIU Jie ^b,,

1.
a School of Chemistry and Chemical Engineering, Nantong University, Nantong;
2.
b Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001

Corresponding author: LIU Jie,
Received Date: 20 July 2007
Available Online: 26 November 2007
Fund Project: 南通市应用研究科技计划项目(K2006018) (K2006018)

The electrochemical behavior of amlodipine (AM) at the multi-wall carbon nanotube (MWCNT) modified glassy carbon electrode (GCE) was investigated by cyclic voltammetry (CV),linear sweep volta-mmetry (LSV) and differential pulse voltammetry (DPV).The experimental parameters were optimized,and a direct electroanalytical method for determining AM was developed.The oxidation peak current of AM was enhanced significantly at the MWCNT modified GCE,in contrast to that at the bare GCE.Under the optimized experimental conditions,the oxidation peak current varied linearly with the concentration of AM over a range from 1.0×10^-7 to 7.5×10^-5 mol/L with a detection limit of 4.0×10^-8 mol/L.The relative standard deviation (RSD) for 1.0×10^-5 mol/L AM was approximately 4.2% (n=10).AM in pharmaceutical formulations was determined by method.
- amlodipine,
- voltammetry,
- carbon nanotube,
- chemically modified electrode
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