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Citation: YANG Rui-Sheng, HU Guo-Qiang, XIE Song-Qiang, HUANG Wen-Long. Synthesis and Antitumor Activity of 3-Methylthio-4-amino-5-pyridin-3-yl-1,2,4-triazole Schiff bases[J]. Chinese Journal of Applied Chemistry, ;2008, 25(7): 783-786. shu

Synthesis and Antitumor Activity of 3-Methylthio-4-amino-5-pyridin-3-yl-1,2,4-triazole Schiff bases

1.
a Institute of Pharmacy, Henan University, Kaifeng 475004;
2.
b Luzhou Medical, Luzhou;
3.
c China Phamaceutical University, Nanjin

Corresponding author: HU Guo-Qiang,
Received Date: 25 July 2007
Available Online: 11 November 2007
Fund Project: 国家自然科学基金(30070681) (30070681)

To discover a novel structural lead compound for developing antitumor agents,4-amino-5-pyridin-3-yl-1,2,4-triazole-3-thiol (1) was S-etherized with iodomethane to give the intermediate of 4-amino-3-methylsulfanyl-5-pyridin-3-yl-1,2,4-triazole (2) followed by condensation with various aromatic aldehydes to afford the title compounds of seven novel Schiff bases,4-(aromatic methyl) imino-3-methylsulfanyl-5-pyridin-3-yl-1,2,4-triazoles (3a~3g).Their antitumor activity against SMMC-7721 and Bel-7402 cells were evaluated by MTT method in vitro,and their structures were characterized by IR,¹H NMR,MS spectrum data and elemental analysis.Among synthesized compounds,3c,3e and 3f showed potential antitumor activity with the IC₅₀ of 3.8,2.0,1.3 and 2.5,2.5,1.1 μmol/L against SMMC-7721 and Bel-7402 cells,respectively.
- s-triazole,
- Schiff base,
- pyridine,
- synthesis,
- antitumor activity
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