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Citation: HE Shi-Hua, WANG Chun-Ting. Synthesis of 3β-Acetoxy-androstan-Δ^5,15-dien-17-one from IBX Selective Dehydrogen of Dehydroepiandrosterone Acetate[J]. Chinese Journal of Applied Chemistry, ;2008, 25(8): 992-994. shu

Synthesis of 3β-Acetoxy-androstan-Δ^5,15-dien-17-one from IBX Selective Dehydrogen of Dehydroepiandrosterone Acetate

HE Shi-Hua ^a,, ,
WANG Chun-Ting ^b

1.
a Department of Chemistry and Chemical Engineering, Xi'an University of Science and Technology, Xi'an 710054;
2.
b Institute of Neuroscience, Forth Military Medicine University, Xi'an

Corresponding author: HE Shi-Hua,
Received Date: 7 August 2007
Available Online: 8 November 2007

3β-Acetoxy-androstan-Δ^5,15-dien-17-one was conveniently and effectively synthesized from IBX selective dehydrogen of dehydroepiandrosterone acetate in DMSO-toluene at 65~70℃ for 22 h, and the effect of the molar ratio of IBX to dehydroepiandrosterone on the yield of target product was probed, indicating that the weight yield was optimal up to 73% when the molar ratio of IBX to dehydroepiandrosterone was 1.5. The chemical structure of target product was characterized by UV, IR, ¹H NMR, MS, and elemental analysis.
- dehydroepiandrosterone acetate,
- IBX,
- β-acetoxy-androstan-Δ^5,15-dien-one,
- α,β-unsaturated carbonyl steroid,
- intermediates
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Synthesis of 3β-Acetoxy-androstan-Δ5,15-dien-17-one from IBX Selective Dehydrogen of Dehydroepiandrosterone Acetate

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通讯作者: 陈斌, bchen63@163.com

Synthesis of 3β-Acetoxy-androstan-Δ^5,15-dien-17-one from IBX Selective Dehydrogen of Dehydroepiandrosterone Acetate