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Citation: HU Yu-Feng, LUO Juna, LIANG Zheng-Yong, HUANG Cheng-Mei, LV Chun-Xu. Synthesis of Fluoronitrobenzenes by Fluorodenitration[J]. Chinese Journal of Applied Chemistry, ;2008, 25(11): 1356-1360. shu

Synthesis of Fluoronitrobenzenes by Fluorodenitration

1.
a School of Chemical Engineering, Nanjing University of Scienceand Technology, Nanjing 210094;
2.
b School of Chemical Engineering, Zhengzhou University, Zhengzhou

Corresponding author: LV Chun-Xu,
Received Date: 30 October 2007
Available Online: 26 February 2008

Fluorodenitration is one of the efficient methods for preparation of fluoronitrobenzenes with the advantages of raw material availability,simple process,and high product yields.In this paper,fluorodenitration of dinitrobenzenes was studied.The effects of fluorinating agent,solvent,reaction time,and catalyst,etc on the fluorodenitration were studied.The results show the optimum reaction conditions were 2.1 g(12.5 mmol) of dinitrobenzene,2.9 g(50 mmol) of SD-KF,0.53 g(1.25 mmol) of Ph₄PBr,0.13 mL(2.5 mmol) of tetraethylene glycol dimethyl ether in the presence of 1.8 mL(12.5 mmol) of PDC as a trapping agent of NO₂^-,and the mixture was stirred at 210℃ for 1~5 h in nitrobenzene,resulting in 94.1%~98.5% conversions and 81.6%~87.4% yields.
- dinitrobenzenes,
- fluoronitrobenzenes,
- fluorodenitration,
- phase transfer catalysis
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