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Citation: LU Xian-Hai, ZHANG Xiu-Li, TANG Wen-Ming. Synthesis and Antibacterial Activity of Cinnamic Acyl Thiourea Derivatives[J]. Chinese Journal of Applied Chemistry, ;2008, 25(11): 1286-1290. shu

Synthesis and Antibacterial Activity of Cinnamic Acyl Thiourea Derivatives

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a College of Science, Anhui Agricultural University, Hefei 230036;
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b Fine Chemical Research and Development Center, Green Pesticide and Agricultural Bioengineering Laboratory of the Ministry of Education, Guizhou University, Guiyang 550025

Corresponding author: TANG Wen-Ming,
Received Date: 27 October 2007
Available Online: 30 December 2007
Fund Project: 国家重点基础研究计划(2003CB114404) (2003CB114404)安徽省科技厅重点科研基金(06023092c) (06023092c)安徽省教育厅青年教师基金(2007jq1054)资助项目 (2007jq1054)

Eleven new thiourea derivatives were synthesized by acylchlorination and then thioureation of cinnamic acid.The structures of the new compounds were confirmed by ¹H NMR,¹³C NMR and IR spectra and elemental analysis.Preliminary results of biological activity test indicates that some of them have certain inhibitory activity against Gibberella zeae and Rhizoctonia solani.Compound 3b exhibited 53.5% inhibition of Gibberella zeae and compound 3f exhibited 54.0% inhibition of Rhizoctonia solani at 250 mg/L.
- cinnamic acid,
- acyl thiourea,
- phase transfer catalysis,
- synthesis,
- biological activity
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