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Citation: YAN Man, SHI De-Qing, WANG Hui-Li. Synthesis and Biological Activities of N-{1-[substituted pyridyl(thiazolyl)methyl]-5-methyl-1H-1,2,3triazol-4-formyl}-N'-(aryloxyacetyl) hydrazines[J]. Chinese Journal of Applied Chemistry, ;2008, 25(11): 1266-1270. shu

Synthesis and Biological Activities of N-{1-[substituted pyridyl(thiazolyl)methyl]-5-methyl-1H-1,2,3triazol-4-formyl}-N'-(aryloxyacetyl) hydrazines

1.
Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079

Corresponding author: SHI De-Qing,
Received Date: 27 October 2007
Available Online: 16 December 2007
Fund Project: 国家自然科学基金(20302002) (20302002)教育部留学回国人员基金(2007[1108])资助项目 (2007[1108])

In order to develop novel high activity and low toxicity agrochemicals,a series of title compounds were synthesized by the muti-step reaction with 2-chloro-5-(chloromethyl)pyridine and 2-chloro-5-(chloro-methyl)thiazole as the starting materials,followed by the cyclization with ethyl acetoacetate,hydrolysis,halogenation and condensation with aryloxyacetyl hydrazines.Their structures were confirmed by IR,¹H NMR,EI-MS and elemental analyses.Preliminary bioassays indicate that most of the target compounds possess good herbicidal activity,but do not display strong insecticidal activity.
- pyridine,
- thiazole,
- triazole,
- diacylhydrazine,
- biological activity
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