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Citation: WANG Jun, ZHANG Yuan-Yuan, ZHANG Lei, WANG Xiao-Fang, XU Rui, GUO Ying, ZHANG Xiang-Dong. Sonodynamic Damage of Bovine Serum Albumin(BSA) under Ultrasonic Irradiation in the Presence of Methylene Blue(MB)[J]. Chinese Journal of Applied Chemistry, ;2008, 25(12): 1399-1403. shu

Sonodynamic Damage of Bovine Serum Albumin(BSA) under Ultrasonic Irradiation in the Presence of Methylene Blue(MB)

1.
a Chemistry;
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b Department;Pharmaceutics Department, Liaoning University, Shenyang 110036

Corresponding author: WANG Jun,
Received Date: 26 November 2007
Available Online: 9 March 2008
Fund Project: 国家自然科学基金(20371023) (20371023)辽宁省教育厅自然科学基金(2004C018)资助项目 (2004C018)

The damage of bovine serum albumin(BSA) molecules under the action of methylene blue(MB) activated by ultrasonic irradiation was detected by UV-Vis spectroscopy and fluorescence spectroscopy,and influencing factors such as ultrasonic irradiation time,MB concentration and pH value on the damage of BSA molecules were also investigated.The results show that under certain conditions,the damage of BSA molecules was enhanced with the increases of the ultrasonic irradiation time,MB concentration,and pH value,that is,UV-Vis spectra showed more and more obvious hyperchromic effect and fluorescence spectra exhibited more and more obvious quenching effect.In addition,the possible mechanism of sonodynamic damage of BSA molecules from MB activated by ultrasound was also discussed in this work.The result has certain significance for the application of photosensitive drugs to sonodynamic therapy(SDT).
- ultrasound,
- methylene blue(MB),
- bovine serum albumin(BSA),
- damage
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