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Citation: LI Xiaohong, YANG Tianlin, WANG Min, HUO Lina, LI Yanping. Synthesis and Biological Activities of 3,5-Diiodo-salicylalidehyde and o-Diaminobenzene Schiff Base and Its Ni(Ⅱ) Complex[J]. Chinese Journal of Applied Chemistry, ;2013, 30(1): 43-47. doi: DOI:10.3724/SP.J.1095.2013.20021 shu

Synthesis and Biological Activities of 3,5-Diiodo-salicylalidehyde and o-Diaminobenzene Schiff Base and Its Ni(Ⅱ) Complex

1.
Key Laboratory of Energy Sources and Chemical Engineering, College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China

Corresponding author: YANG Tianlin,
Received Date: 13 January 2012
Available Online: 1 March 2012
Fund Project: 国家自然科学基金(20962016,21261018) (20962016,21261018)教育部科学技术研究重点基金(208159)资助项目 (208159)

The Schiff base consisted of 3,5-diiodo-salicylalidehyde and o-diaminobenzene(L) and its Ni(Ⅱ) metal complex has been synthesized and characterized by ¹H NMR,elemental analysis,UV spectra,IR spectra and molar conductance analysis.The main bond parameters of the complex were calculated by full-optimized molecular geometry using Gaussian03 program.The composition of the complex was determined to be Ni(Ⅱ)L.The binding mode between complex and DNA was investigated by UV spectra,viscosities,and DNA competitive binding with ethidium bromide(EB).The results showed that the intensity of absorption peaks increased when the complex interacted with ct-DNA,and its constant was K_b=1.129×10⁵ L/mol.The complex will lead to dramatic decrease of fluorescent intensity of EB-DNA.The relative viscosity of ct-DNA increased with the concentration increase of the complex.All indicated that the complex was intercalated into ct-DNA.In addition,the complex is assayed against M.luteus by the punch method.
- iodine-containing Schiff base,
- Ni(Ⅱ) complex,
- spectrum property,
- DNA intercalative binding mode,
- antibacterial activity
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