Citation: Yan Lin, Ren Yongshuo, Wang Xuejing, Mu Wei, Han Xiaojun. Coacervate and Its Application in the Field of Artificial Cells[J]. Acta Chimica Sinica, ;2020, 78(11): 1150-1163. doi: 10.6023/A20060253 shu

Coacervate and Its Application in the Field of Artificial Cells

State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001

Corresponding author: Mu Wei, muwei@hit.edu.cn Han Xiaojun, hanxiaojun@hit.edu.cn
Received Date: 20 June 2020
Available Online: 5 August 2020
Fund Project: the National Natural Science Foundation of China 21773050the Natural Science Foundation of Heilongjiang Province for Distinguished Young Scholars JC2018003the National Natural Science Foundation of China 21929401Project supported by the National Natural Science Foundation of China (Nos. 21773050, 21929401) and the Natural Science Foundation of Heilongjiang Province for Distinguished Young Scholars (No. JC2018003)

Figures(6)

The origin of life attracts more and more attentions of researchers. Synthetic biologists are devoting to construct a simple and rational system which can exist in primitive earth. Coacervate is a phase separation system which is formed by the interactions of polyelectrolyte. It's a rational protocell model. So far, coacervate has been found to present as membraneless organelles in natural cells. Therefore, the construction of coacervate as artificial organelles is emerging. The formation mechanism, characteristics and categories of coacervate are reviewed in this paper. Additionally, the applications of coacervate as protocell and artificial organelles are summarized. The existing scientific problems and the future development directions are provided at the end of this paper.
- coacervate,
- artificial cells,
- liquid/liquid phase separation,
- electrostatic interaction,
- artificial organelle,
- collective behavior
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