Citation: Guo Wenjuan, Yu Jie, Dai Zhao, Hou Weizhao. A New Method for Enriching baicalin in Scutellaria baicalensis Georgi by Metal Organic Framework Material ZIF-8[J]. Acta Chimica Sinica, ;2019, 77(11): 1203-1210. doi: 10.6023/A19080316 shu

A New Method for Enriching baicalin in Scutellaria baicalensis Georgi by Metal Organic Framework Material ZIF-8

Tianjin Polytechnic University, School of Chemistry and Chemical Engineering, Tianjin 300387

Corresponding author: Guo Wenjuan, guowenjuan@tjpu.edu.cn
Received Date: 29 August 2019
Available Online: 21 November 2019

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This work aims to explore a new method for the efficient enrichment of baicalin in Scutellaria baicalensis Georgi by using metal organic frameworks (MOFs) materials, and to open up new applications for MOFs in the adsorption direction. The zeolitic imidazolate framework-8 (ZIF-8) was synthesized by solvothermal method and characterized by structure to ensure its accurate synthesis. Baicalin was extracted from Scutellaria baicalinsis Georgi by ethanol extraction and acid precipitation method. The ZIF-8 was used to carry out the static adsorption experiment on the crude extract of Radix Scutellariae. After the adsorption equilibrium was reached, the mixture was centrifuged, and the residual concentration of baicalin was detected by high performance liquid chromatography method (HPLC). The recovered saturated adsorbed ZIF-8 material was washed with water and dried, and the phosphate buffered saline (PBS) solution of pH 6.8 was used as a desorption solution, and the desorption was performed by shaking. The content of baicalin in the desorbed solution was determined by HPLC to calculate the desorption rate and achieve the purpose of adsorbent recovery. In the adsorbing process, the effects of adsorbent dosage, pH and adsorbate concentration of the crude extract of Radix Scutellariae were also optimized, and the response surface test (RSM) was performed using Design Expert software to obtain optimal adsorption conditions. Under these conditions, the adsorption rate of ZIF-8 to baicalin in Radix Scutellariae was as high as 98.22%, and the adsorption effect was not significant on other components in Radix Scutellariae. The desorption rate of ZIF-8 adsorbed baicalin in pH 6.8 solution was 62.46%, and the purity of baicalin increased from 21.55% before adsorption to 64.27% after desorption, and ZIF-8 had good stability before and after adsorption, and the recovery rate reached 83.50%. Therefore, ZIF-8 has potential application value in the adsorption and purification of baicalin. The adsorption law and mechanism of ZIF-8 on baicalin were studied:The adsorption of baicalin on ZIF-8 accorded with the quasi-second-order kinetic equation, and the equilibrium adsorption data accorded with the Langmuir adsorption isotherm model.
- metal-organic framework,
- adsorption,
- X-ray photoelectron spectroscopy
1. [1]
  Farha, O. K.; Hupp, J. T. Acc. Chem. Res. 2010, 43, 1166. doi: 10.1021/ar1000617
2. [2]
  Elsaidi, S. K.; Mohamed, M. H.; Banerjee, D.; Thallapally, P. K. Coord. Chem. Rev. 2017, 358, 125.
3. [3]
  Yang, T.; Cui, Y. N.; Chen, H. Y.; Li, W. H. Acta Chim. Sinica 2017, 75, 339(in Chinese).
4. [4]
  Zhang, H.; Li, G. L.; Zhang, K. G.; Liao, C. Y. Acta Chim. Sinica 2017, 75, 841(in Chinese).
5. [5]
  Cheon, Y. E.; Park, J.; Suh, M. P. Chem. Commun. 2009, 36, 5436.
6. [6]
  Baa, E.; Watkins, G. M.; Krause, R. W.; Tantoh, D. N. Chin. J. Chem. 2019, 37, 387.
7. [7]
  Pang, C. M.; Luo, S. H.; Hao, Z. F.; Gao, J.; Huang, Z. H.; Yu, J. H.; Yu, S. M.; Wang, Z. Y. Chin. J. Org. Chem. 2018, 38, 2606(in Chinese).
8. [8]
  Tang, Y. Z.; Huang, H. L.; Peng, Y. G.; Ruan, Q. Q.; Wang, K. K.; Yi, P. D.; Liu, D. H.; Zhong, C. L. Chin. J. Chem. 2017, 35, 1091. doi: 10.1002/cjoc.201600876
9. [9]
  Wu, Z. M.; Shi, Y.; Li, C. Y.; Niu, D. Y.; Chu, Q.; Xiong, W.; Li, X. Y. Acta Chim. Sinica 2019, 77, 758(in Chinese).
10. [10]
  Guo, X. L.; Chen, X.; Su, D. S.; Liang, C. H. Acta Chim. Sinica 2018, 76, 22(in Chinese). doi: 10.3866/PKU.WHXB201706302
11. [11]
  Yang, X. P.; Guo, X. X.; Zhang, C. H.; Wang, X. P.; Yang, Y.; Li, Y. W. Acta Chim. Sinica 2017, 75, 360(in Chinese).
12. [12]
  Chouhan, A.; Pilet, G.; Daniele, S.; Pandey, A. Chin. J. Chem. 2017, 35, 209. doi: 10.1002/cjoc.201600685
13. [13]
  Zhang, W. Q.; Li, Q. Y.; Yang, X. Y.; Ma, Z.; Wang, H. H.; Wang, X. J. Acta Chim. Sinica 2017, 75, 80(in Chinese). doi: 10.3866/PKU.WHXB201607293
14. [14]
  Mohamedali, M.; Ibrahim, H.; Henni, A. Chem. Eng. J. 2018, 334, 817. doi: 10.1016/j.cej.2017.10.104
15. [15]
  Bian, L.; Li, W.; Wei, Z. Z.; Liu, X. W.; Li, S. Acta Chim. Sinica 2018, 76, 303(in Chinese) doi: 10.3866/PKU.WHXB201708302
16. [16]
  Massoudinejad, M.; Ghaderpoori, M.; Shahsavani, A.; Amini, M. M. J. Mol. Liq. 2016, 221, 279. doi: 10.1016/j.molliq.2016.05.087
17. [17]
  Chen, Z. Y.; Liu, J. W.; Cui, H.; Zhang, L.; Su, C. Y. Acta Chim. Sinica 2019, 77, 242(in Chinese). doi: 10.3969/j.issn.0253-2409.2019.02.014
18. [18]
  Li, Y.; Zou, B.; Xiao, A. S.; Zhang, H. X. Chin. J. Chem. 2017, 35, 1501. doi: 10.1002/cjoc.201700151
19. [19]
  Hasan, Z.; Jhung, S. H. J. Hazard. Mater. 2015, 283, 329. doi: 10.1016/j.jhazmat.2014.09.046
20. [20]
  Pi, Y. H.; Li, X. Y.; Xia, Q. B.; Wu, J. L.; Li, Y. W.; Xiao, J.; Li, Z. Chem. Eng. J. 2018, 337, 351. doi: 10.1016/j.cej.2017.12.092
21. [21]
  Dai, J.; Xiao, X.; Duan, S. X.; Liu, J.; He, J.; Lei, J. D.; Wang, L. Y. Chem. Eng. J. 2018, 331, 64. doi: 10.1016/j.cej.2017.08.090
22. [22]
  Massoudinejad, M.; Ghaderpoori, M.; Shahsavani, A.; Jafari, A.; Kamarehie, B.; Ghaderpoury, A.; Amini, M. M. J. Mol. Liq. 2018, 255, 263. doi: 10.1016/j.molliq.2018.01.163
23. [23]
  Li, J.; Wu, Y. N.; Li, Z. H.; Zhang, B. R.; Zhu, M.; Hu, X.; Zhang, Y. M.; Li, F. T. J. Phys. Chem. C 2014, 118, 47.
24. [24]
  Sun, X.; Hu, C. Q.; Huang, X. D.; Dong, J. C. Chin. J. Org. Chem. 2003, 23, 81(in Chinese).
25. [25]
  Chou, T. C.; Chang, L. P.; Li, C. Y.; Wong, C. S.; Yang, S. P. Anesth. Analg. 2003, 97, 1724. doi: 10.1213/01.ANE.0000087066.71572.3F
26. [26]
  Dinda, B.; Dinda, S.; DasSharma, S.; Banik, R.; Chakraborty, A.; Dinda, M. Eur. J. Med. Chem. 2017, 131, 68. doi: 10.1016/j.ejmech.2017.03.004
27. [27]
  Li-Weber, M. Cancer Treat. Rev. 2009, 35, 57. doi: 10.1016/j.ctrv.2008.09.005
28. [28]
  Ikemoto, S.; Sugimura, K.; Yoshida, N.; Yasumoto, R.; Wada, S.; Yamamoto, K.; Kishimoto, T. J. Urol. 2000, 55, 951. doi: 10.1016/S0090-4295(00)00467-2
29. [29]
  Wu, J. A.; Attele, A. S.; Zhang, L.; Yuan, C. S. Am. J. Chin. Med. 2001, 29, 69. doi: 10.1142/S0192415X01000083
30. [30]
  Liang, W.; Huang, X. B.; Chen, W. Q. Aging Dis. 2017, 8, 850. doi: 10.14336/AD.2017.0829
31. [31]
  Mou, X. L.; Zhang, W. P.; Chen, Z. L. J. Appl. Polym. Sci. 2013, 130, 1873. doi: 10.1002/app.39410
32. [32]
  Wang, H.; Ma, X. D.; Cheng, Q. B.; Wang, L.; Zhang, L. W. Molecules 2018, 23, 3233. doi: 10.3390/molecules23123233
33. [33]
  Srinivas, N. R. Xenobiotica 2010, 40, 357. doi: 10.3109/00498251003663724
34. [34]
  Huang, X. C.; Lin, Y. Y.; Zhang, J. P.; Chen, X. M. Angew. Chem., Int. Ed. 2005, 45, 1557.
35. [35]
  Park, K. S.; Ni, Z.; Cote, A. P.; Choi, J. Y.; Huang, R. D.; Uribe-Romo, F. J.; Chae, H. K.; O'Keeffe, M.; Yaghi, O. M. Proc. Natl. Acad. Sci. 2006, 103, 10186. doi: 10.1073/pnas.0602439103
36. [36]
  Yao, J. F.; Wang, H. T. Chem. Soc. Rev. 2014, 43, 4470. doi: 10.1039/C3CS60480B
37. [37]
  Phan, A.; Doonan, C. J.; Uribe-Romo, F. J.; Knobler, C. B.; O'Keeffe, M.; Yaghi, O. M. Acc. Chem. Res. 2010, 43, 58. doi: 10.1021/ar900116g
38. [38]
  Lai, Z. P. Curr. Opin. Chem. Eng. 2018, 20, 78. doi: 10.1016/j.coche.2018.03.002
39. [39]
  Pan, Y. C.; Liu, Y. Y.; Zeng, G. F.; Zhao, L.; Lai, Z. P. Chem. Commun. 2011, 47, 2071. doi: 10.1039/c0cc05002d
40. [40]
  The Pharmacopoeia Commission of PRC, The Pharmacopoeia of the People's Republic of China, Part I, Chemical Industry Publishing Press, Beijing, China, 2015, pp. 301~302(in Chinese).
41. [41]
  Li, W. S.; Chen, X. Chinese Traditional and Herbal Drugs 2000, 31, 107(in Chinese). doi: 10.3321/j.issn:0253-2670.2000.02.016
42. [42]
  Dai, Q.; Lei, X. R.; Yang, J. H.; Cheng, Q.; Gao, C.; Li, H. Acta Chim. Sinica 2009, 67, 2363(in Chinese). doi: 10.3321/j.issn:0251-0790.2009.12.007
43. [43]
  Ni, Z. M.; Wang, Q. Q.; Yao, P.; Liu, X. M.; Li, Y. Acta Chim. Sinica 2011, 69, 529(in Chinese).
44. [44]
  Fan, C. H.; Zhang, Y. C.; Zhang, Y. Acta Chim. Sinica 2010, 68, 2175(in Chinese).
45. [45]
  Cao, X. Y.; Li, L.; Chen, H. Acta Chim. Sinica 2010, 68, 1461(in Chinese).
46. [46]
  Venna, S. R.; Carreon, M. A. J. Am. Chem. Soc. 2010, 132, 76. doi: 10.1021/ja909263x
47. [47]
  Xu, Y. L.; Li, X.; Lin, Y. Q.; Malde, C.; Wang, R. J. Membr. Sci. 2019, 585, 238. doi: 10.1016/j.memsci.2019.05.042
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