Citation: Zhou Yiqing, Xiao Youli. Target Identification of Bioactive Natural Products[J]. Acta Chimica Sinica, ;2018, 76(3): 177-189. doi: 10.6023/A17110484 shu

Target Identification of Bioactive Natural Products

Zhou Yiqing ^a ,
Xiao Youli ^a,b,,

a.
CAS Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032
b.
University of Chinese Academy of Sciences, Beijing 100039

Corresponding author: Xiao Youli, ylxiao@sibs.ac.cn
Received Date: 6 November 2017
Available Online: 25 March 2017
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21572243, 21502206) and Chinese Academy of Sciences (No. XDPB0402)the National Natural Science Foundation of China 21502206Chinese Academy of Sciences XDPB0402the National Natural Science Foundation of China 21572243

Figures(8)

Natural products are rich sources of drugs for the treatment of human diseases, while identification of the protein targets and mode of actions is one of the most significant and challenging steps in drug discovery across bioactive natural products. This review describes recent progresses in the methodology of target identification of natural products, highlights examples of target identification utilizing chemical proteomics and biophysical strategies, and discusses the advantages, limitations, applications, and challenges of each strategy.
- natural products,
- target identification,
- chemical proteomics,
- biophysics,
- phenotype screening
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