Citation: Yang Limin, Liu Bo, Li Na, Tang Bo. Fluorescent Nanoprobe for Detection and Imaging of Nucleic Acid Molecules[J]. Acta Chimica Sinica, ;2017, 75(11): 1047-1060. doi: 10.6023/A17080353 shu

Fluorescent Nanoprobe for Detection and Imaging of Nucleic Acid Molecules

College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014

Corresponding author: Li Na, lina@sdnu.edu.cn Tang Bo, tangb@sdnu.edu.cn
Received Date: 3 August 2017
Available Online: 18 November 2017
Fund Project: the National Natural Science Foundation of China 21535004the National Natural Science Foundation of China 21505087Project supported by the 973 Program (No. 2013CB933800), the National Natural Science Foundation of China (Nos. 21390411, 21535004, 21422505, 21375081, 21505087), and the Natural Science Foundation for Distinguished Young Scholars of Shandong Province (No. JQ201503)the National Natural Science Foundation of China 21375081the Natural Science Foundation for Distinguished Young Scholars of Shandong Province JQ201503the National Natural Science Foundation of China 21390411the National Natural Science Foundation of China 21422505the 973 Program 2013CB933800

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Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), play important roles in normal or abnormal life activities. DNA is an important genetic material and carrier of genetic information. It plays an important role in cell division, biological development, mutation, cancer, etc. RNA includes mRNA, tRNA, microRNA (miRNA) and small RNA. Tumor-associated mRNA has been widely used as a specific marker to assess the migration of tumor cells, and its expression level is related to the tumor burden and malignant progression. MiRNA is a non-coding small molecule RNA that regulates at least 30% of the genes. MiRNA is involved in most of the biological process, such as proliferation, differentiation, senescence, migration and apoptosis. The abnormal expression of DNA, mRNA and miRNA is closely associated with the occurrence and development of multiple diseases. Therefore, developing accurate and effective methods for detecting nucleic acid molecules is of great significance for studying the function of nucleic acid regulation and achieving the early detection and treatment of diseases. Fluorescence detection method and imaging technology provide powerful tools for real-time and accurately detecting nucleic acid molecules due to their high sensitivity and temporal resolution. Fluorescent nanoprobe has many advantages such as good biocompatibility, good solubility and so on. It has been widely used in the detection of nucleic acid molecules for further understanding the roles of nucleic acid in many diseases. In this review, we have showed the roles of various nucleic acid molecules in life activities and illustrated the advances in the development of fluorescent nanoprobe for detection of disease-related DNA, mRNA and miRNA in live cells and in vivo in recent years. The preparation of these nanoprobe, detection mechanism and imaging application were also presented. Finally, the challenge and future development of constructing new fluorescent nanoprobe for nucleic acids detection were proposed.
- fluorescent nanoprobe,
- nucleic acids,
- detection,
- live cells,
- in vivo,
- fluorescent imaging
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