Citation: Qian Guangsheng, Zhao Wei, Xu Jingjuan, Chen Hongyuan. Highly Sensitive Detection of Mercury Ion Based on Plasmon Coupling[J]. Acta Chimica Sinica, ;2017, 75(11): 1097-1102. doi: 10.6023/A17060290 shu

Highly Sensitive Detection of Mercury Ion Based on Plasmon Coupling

State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023

Corresponding author: Zhao Wei, weizhao@nju.edu.cn Xu Jingjuan, xujj@nju.edu.cn
Received Date: 30 June 2017
Available Online: 7 November 2017
Fund Project: the National Natural Science Foundation of China 21535003the National Natural Science Foundation of China 21327902Project supported by the National Natural Science Foundation of China (Nos. 21327902, 21535003)

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Mercury is very harmful to the environment and human health even at low concentration. Methods for sensitive detection of mercury ion (Hg²⁺) have increasingly been developed over the past decade owing to the rapid development in nanotechnology. However, the limits of detection (LODs) of these methods are mostly not satisfactory enough to meet the demand of monitoring trace amounts of mercury ion. DNA thymine (T bases) can react with the mercury ion to form T-Hg²⁺-T structure, and this interaction has been proved to be much more stable than the interaction between thymine and its complementary adenine (A bases). Based on this principle, a series of ultra-sensitive DNA-based colorimetric biosensors, mostly using Au nanoparticles (AuNPs) as DNA carriers, have been designed for detection of mercury ion. In this study, we report a new strategy for highly sensitive Hg²⁺ detection based on Hg²⁺-induced AuNPs assembly. AuNPs of different sizes (s-AuNPs of 18 nm and c-AuNPs of 52 nm) were modified with oligonucleotides containing a sequence of continuous T bases. In the presence of Hg²⁺, s-AuNPs would be bound to c-AuNPs in the solution owing to oligonucleotide hybridization, forming a core-satellites nanostrucure. This process was accompanied by a color change of the scattering light from green to orange as observed under dark-field microscopy and a corresponding distinct scattering peak shift. The scattering spectra of the AuNPs were obtained using a spectroscopic system which was established autonomously. The scattering peak shift of color-changed spots corresponded with Hg²⁺ concentration. It was increased linearly with logarithm of Hg²⁺ concentration over a wide range from 1 pmol/L to 1 nmol/L, with the correlation coefficient of 0.983 (R²=0.983), and the detection limit of Hg²⁺ was estimated to be 1 pmol/L. Other metal ions, such as Ag⁺, K⁺, Ca²⁺, Mg²⁺, Zn²⁺, Cd²⁺, Fe²⁺, Pb²⁺, Ni²⁺, Mn²⁺, Al³⁺, induced negligible scattering peak shifts for AuNPs under the same conditions, which showed that this strategy exhibited excellent selectivity towards Hg²⁺. Moreover, satisfactory results were obtained when the proposed approach was applied to detect Hg²⁺ in real samples with recoveries of 98.7%~103.1% and 105.6%~108.2% for river water and tap water, respectively.
- mercury ion,
- nanoassembly,
- T-Hg²⁺-T,
- plasmon coupling
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