Citation: Zhou Qianxiong, Wang Xuesong. Advances in Ru (Ⅱ)-based Photoactivated Chemotherapy Agents[J]. Acta Chimica Sinica, ;2017, 75(1): 49-59. doi: 10.6023/A16090470 shu

Advances in Ru (Ⅱ)-based Photoactivated Chemotherapy Agents

Zhou Qianxiong ^*,, ,
Wang Xuesong ^*,,

Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190

Corresponding author: Zhou Qianxiong, zhouqianxiong@mail.ipc.ac.cn Wang Xuesong, xswang@mail.ipc.ac.cn
Received Date: 5 September 2016

Fund Project: the National Natural Science Foundation of China 21273259the National Natural Science Foundation of China 21571181

Figures(11)

Many Ru (Ⅱ) complexes can undergo photoinduced ligand dissociation in aqueous solutions, and the formed aqua Ru (Ⅱ) species may bind to DNA covalently. This property has been applied to develop novel photoactivated chemotherapy (PACT) agents for cancer treatment in recent years. By finely tuning ligand structures and coordination configurations, PACT may realize highly selective and on-demand release of active species in cancer tissues, leading to an improved efficacy and diminished side effects. In this review, the progress in Ru (Ⅱ)-based PACT agents was fully discussed and a perspective for their future development was included.
- chemical therapy,
- photoactivation,
- Ru (Ⅱ) complexes,
- ligand dissociation
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沈阳化工大学材料科学与工程学院沈阳 110142