Citation: Zhang Shaofei, Yang Jiandong, Liu Mingzhu, Lü Shaoyu, Gao Chunmei, Wu Can, Zhu Zhaoyan. Synthesis of Peptide Dendrimers and Their Application in the Drug Delivery System[J]. Acta Chimica Sinica, ;2016, 74(5): 401-409. doi: 10.6023/A16020096 shu

Synthesis of Peptide Dendrimers and Their Application in the Drug Delivery System

Zhang Shaofei ^a,b ,
Yang Jiandong ^b ,
Liu Mingzhu ^a,*,, ,
Lü Shaoyu ^a ,
Gao Chunmei ^a ,
Wu Can ^a ,
Zhu Zhaoyan ^a

a.
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000
b.
Longnan Teacher's College, Longnan 742500

Corresponding author: Liu Mingzhu,
Received Date: 22 February 2016

Fund Project: the National Natural Science Foundation of China 51541304the National Natural Science Foundation of China 51273086Key Research Project of Longnan Teacher's College 2014LSZK01004Special Doctorial Program Fund from the Ministry of Education of China 20130211110017

Figures(12)

Dendrimers are a novel polymer material, which have received more and more attention due to the functional groups on their surface, hydrophobic cavity and adjustable sizes. Thus, dendrimers have been widely used in many fields. Peptide dendrimer is a sort of dendritic polymer, which contains peptide bonds in the structure. Owing to the globular structure similar to the protein, excellent water solubility, biocompatibility, biodegradability and low toxicity, peptide dendrimer could be used as drug delivery carrier. In addition, hydrophobic cavity can be used to solubilize hydrophobic drugs, in which the drugs can be released slowly. The present review highlights the current status of synthesis of peptide dendrimers, and it also summarizes and forecasts the interaction mechanism between drug molecules and peptide dendrimers, and the application of peptide dendrimers in drug delivery system.
- polymer material,
- peptide dendrimers,
- globular structure,
- drug delivery,
- carrier
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