Citation: Xu Yanglei, Meng Zheyi, Zhai Jin. pH and Calcium Cooperative Regulation Nanofluidic Gating Device[J]. Acta Chimica Sinica, ;2016, 74(6): 538-544. doi: 10.6023/A16010053 shu

pH and Calcium Cooperative Regulation Nanofluidic Gating Device

1.
Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry and Environment, Beihang University, Beijing 100191

Corresponding author: Zhai Jin, zhaijin@buaa.edu.cn
Received Date: 25 January 2016

Fund Project: the National Basic Research Program of China 2012CB720904the National Natural Science Foundation of China 21271016

Figures(8)

In living body, Ca²⁺-responsive ion channels play crucial roles in many biological activities. Inspired by nature, the design and fabrication of artificial smart nanochannels system become a very significant research subject, mimicking the biological Ca²⁺-responsive signals in ion channels. In this article, by using track-etched artificial polyethylene terephthalate (PET) multiporous membrane materials and modifying intelligent molecules O-Phospho-L-tyrosine (OPLT) through chemical modification method, we demonstrate a new biomimetic artificial smart responsive ion channel system, which presents the cooperative response to pH and calcium. The nanosystem shows ion selective transport, ion gating and ion rectification property, which is similar to the property of biological Ca²⁺-responsive ion channels. And the cooperative responsive property of pH and calcium in OPLT modified nanochannels was also investigated by measuring the current-voltage (I-V) curves. At a low pH value, the surface charge of the nanochannels walls is positive as a result of the amino group (NH₃⁺) of OPLT, the nanosystem attracts the anions and inhibits the cations due to electrostatic interactions between the anions passing through the nanochannels and the nanochannels cations walls, resulting in ion current rectification property. Meanwhile, after adding calcium to the nanosystem, no significant changes of ion current are found. The system presents no calcium responsive property. At a high pH value, the surface charge of the nanochannels walls is negative due to the phosphate group (HPO₄^2-) of OPLT, the nanosystem shows cations-selective. After adding calcium to the solution, the bonding of phosphate group (HPO₄^2-) with calcium (Ca²⁺) results in the neutralization of the surface charge in the nanochannels. This nanochannels switch the polarity of ion transport from cation-selective to non-selective, and turn from the highly conductive state to the low conductive state. The significant decline of the ion current can be observed. Thus, the OPLT modified nanofluidic gating device displays the cooperative effect of pH and calcium. This system provides a new idea for the multiple signal induced ion gating in conical nanochannel devices.
- calcium gating,
- ion channels,
- rectification,
- pH response,
- nanofluidic
1. [1]
  Clapham, D. E. Cell 2007, 131, 1047. doi: 10.1016/j.cell.2007.11.028
2. [2]
  Matulef, K.; Zagotta, W. N. Annu. Rev. Cell Dev. Biol. 2003, 19, 23. doi: 10.1146/annurev.cellbio.19.110701.154854
3. [3]
  Liao, J.; Li, H.; Zeng, W. Z.; Sauer, D. B.; Belmares, R.; Jiang, Y. X. Science 2012, 335, 686. doi: 10.1126/science.1215759
4. [4]
  Berridge, M. J.; Bootman, M. D.; Roderick, H. L. Nat. Rev. Mol. Cell Biol. 2003, 4, 517.
5. [5]
  Methfessel, C.; Boheim, G. Biophys. Struct. Mech. 1982, 9, 35. doi: 10.1007/BF00536014
6. [6]
  Saimi, Y.; Kung, C. Annu. Rev. Physiol. 2002, 64, 289. doi: 10.1146/annurev.physiol.64.100301.111649
7. [7]
  Eismann, E.; Muller, F.; Heinemann, S. H.; Kaupp, U. B. Proc. Natl. Acad. Sci. U. S. A. 1994, 91, 1109. doi: 10.1073/pnas.91.3.1109
8. [8]
  McNally, B.; Somasundaram, A.; Yamashita, M.; Prakriya, M. Nature 2012, 482, 241.
9. [9]
  Ali, M.; Nasir, S.; Ramirez, P.; Cervera, J.; Mafe, S.; Ensinger, W. ACS Nano 2012, 6, 9247. doi: 10.1021/nn303669g
10. [10]
  Siwy, Z. S.; Powell, M. R.; Petrov, A.; Kalman, E.; Trautmann, C.; Eisenberg, R. S. Nano Lett. 2006, 6, 1729. doi: 10.1021/nl061114x
11. [11]
  Deniaud, A.; Rossi, C.; Berquand, A.; Homand, J.; Campagna, S.; Knoll, W.; Brenner, C.; Chopineau, J. Langmuir 2007, 23, 3898. doi: 10.1021/la063105+
12. [12]
  Siwy, Z. S.; Powell, M. R.; Kalman, E.; Astumian, R. D.; Eisenberg, R. S. Nano Lett. 2006, 6, 473. doi: 10.1021/nl0524290
13. [13]
  Vilozny, B.; Actis, P.; Seger, R. A.; Vallmajo-Martin, Q.; Pourmand, N. Anal. Chem. 2011, 83, 6121. doi: 10.1021/ac201322v
14. [14]
  He, Y.; Gillespie, D.; Boda, D.; Vlassiouk, I.; Eisenberg, R.; Siwy, Z. S. J. Am. Chem. Soc. 2009, 131, 5194. doi: 10.1021/ja808717u
15. [15]
  García-Gimenez, E.; Alcaraz, A.; Aguilella, V. M.; Ramírez, P. J. Membr. Sci. 2009, 331, 137. doi: 10.1016/j.memsci.2009.01.026
16. [16]
  Powell, M. R.; Sullivan, M.; Vlassiouk, I.; Constantin, D.; Sudre, O.; Martens, C. C.; Eisenberg, R. S.; Siwy, Z. S. Nat. Nanotechnol. 2008, 3, 51. doi: 10.1038/nnano.2007.420
17. [17]
  Hou, X.; Guo, W.; Jiang, L. Chem. Soc. Rev. 2011, 40, 2385. doi: 10.1039/c0cs00053a
18. [18]
  Regonda, S.; Tian, R.; Gao, J.; Greene, S.; Ding, J.; Hu, W. Biosens. Bioelectron. 2013, 45, 245. doi: 10.1016/j.bios.2013.01.027
19. [19]
  Tian, Y.; Jiang, L. Sci. China Chem. 2011, 54, 603.
20. [20]
  Xiao, K.; Xie, G. H.; Li, P.; Liu, Q.; Hou, G. L.; Zhang, Z.; Ma, J.; Tian, Y.; Wen, L. P.; Jiang, L. Adv. Mater. 2014, 26, 6560. doi: 10.1002/adma.v26.38
21. [21]
  Hou, X.; Guo, W.; Nie, F. Q.; Dong, H.; Tian, Y.; Wen, L. P.; Wang, L.; Cao, L. X.; Yang, Y.; Xue, J. M.; Song, Y. L.; Wang, Y. G.; Liu, D. S.; Jiang, L. J. Am. Chem. Soc. 2009, 131, 7800. doi: 10.1021/ja901574c
22. [22]
  Xie, G. H.; Xiao, K.; Zhang, Z.; Kong, X. Y.; Liu, Q.; Li, P.; Wen, L. P.; Jiang, L. Angew. Chem., Int. Ed. 2015, 54, 13664.
23. [23]
  Gao, J.; Guo, W.; Feng, D.; Wang, H. T.; Zhao, D. Y.; Jiang, L. J. Am. Chem. Soc. 2014, 136, 12265. doi: 10.1021/ja503692z
24. [24]
  Hou, X.; Jiang, L. Physics 2011, 40, 304.
25. [25]
  Guo, W.; Jiang, L. Sci. Sin. Chim. 2011, 41, 1257. doi: 10.1360/032011-186
26. [26]
  Zhou, D.; Meng, Z. Y.; Zhang, M. H.; Zhai, J. Acta Chim. Sinica 2015, 73, 716. doi: 10.6023/A15030217
27. [27]
  Meng, Z. Y.; Bao, H.; Wang, J. T.; Jiang, C. D.; Zhang, M. H.; Zhai, J.; Jiang, L. Adv. Mater. 2014, 26, 2329. doi: 10.1002/adma.v26.15
28. [28]
  Xu, Y. L.; Sui, X.; Guan, S.; Zhai, J.; Gao, L. C. Adv. Mater. 2015, 27, 1851. doi: 10.1002/adma.v27.11
29. [29]
  Xu, Y. L.; Zhang, M. H.; Tian, T.; Shang, Y.; Meng, Z. Y.; Jiang, J. Q.; Zhai, J.; Wang, Y. NPG Asia Mater. 2015, 7, e215. doi: 10.1038/am.2015.98
30. [30]
  Zhang, W. J.; Meng, Z. Y.; Zhai, J.; Heng, L. P. Chem. Commun. 2014, 50, 3552. doi: 10.1039/c3cc47999d
31. [31]
  Apel, P. Y.; Korchev, Y. E.; Siwy, Z.; Spohr, R.; Yoshida, M. Nucl. Instrum. Methods Phys. Res., Sect. B 2001, 184, 337. doi: 10.1016/S0168-583X(01)00722-4
32. [32]
  Siwy, Z.; Fulinski, A. Phys. Rev. Lett. 2002, 89, 198103. doi: 10.1103/PhysRevLett.89.198103
33. [33]
  Hou, X.; Zhang, H. C.; Jiang, L. Angew. Chem., Int. Ed. 2012, 51, 5296.
34. [34]
  Siwy, Z. S. Adv. Funct. Mater. 2006, 16, 735. doi: 10.1002/(ISSN)1616-3028
35. [35]
  Hou, X.; Dong, H.; Zhu, D. B.; Jiang, L. Small 2010, 6, 361. doi: 10.1002/smll.v6:3
1. [1]
  Di WU , Ruimeng SHI , Zhaoyang WANG , Yuehua SHI , Fan YANG , Leyong ZENG . Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135
2. [2]
  Rui Li , Huan Liu , Yinan Jiao , Shengjian Qin , Jie Meng , Jiayu Song , Rongrong Yan , Hang Su , Hengbin Chen , Zixuan Shang , Jinjin Zhao . 卤化物钙钛矿的单双向离子迁移. Acta Physico-Chimica Sinica, 2024, 40(11): 2311011-. doi: 10.3866/PKU.WHXB202311011
3. [3]
  Peiran ZHAO , Yuqian LIU , Cheng HE , Chunying DUAN . A functionalized Eu³⁺ metal-organic framework for selective fluorescent detection of pyrene. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 713-724. doi: 10.11862/CJIC.20230355
4. [4]
  Hong LI , Xiaoying DING , Cihang LIU , Jinghan ZHANG , Yanying RAO . Detection of iron and copper ions based on gold nanorod etching colorimetry. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 953-962. doi: 10.11862/CJIC.20230370
5. [5]
  Qingtang ZHANG , Xiaoyu WU , Zheng WANG , Xiaomei WANG . Performance of nano Li₂FeSiO₄/C cathode material co-doped by potassium and chlorine ions. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1689-1696. doi: 10.11862/CJIC.20240115
6. [6]
  Qi Li , Pingan Li , Zetong Liu , Jiahui Zhang , Hao Zhang , Weilai Yu , Xianluo Hu . Fabricating Micro/Nanostructured Separators and Electrode Materials by Coaxial Electrospinning for Lithium-Ion Batteries: From Fundamentals to Applications. Acta Physico-Chimica Sinica, 2024, 40(10): 2311030-. doi: 10.3866/PKU.WHXB202311030
7. [7]
  Zhenming Xu , Mingbo Zheng , Zhenhui Liu , Duo Chen , Qingsheng Liu . Experimental Design of Project-Driven Teaching in Computational Materials Science: First-Principles Calculations of the LiFePO₄ Cathode Material for Lithium-Ion Batteries. University Chemistry, 2024, 39(4): 140-148. doi: 10.3866/PKU.DXHX202307022
8. [8]
  Wenjun Zheng . Application in Inorganic Synthesis of Ionic Liquids. University Chemistry, 2024, 39(8): 163-168. doi: 10.3866/PKU.DXHX202401020
9. [9]
  Xiufang Wang , Donglin Zhao , Kehua Zhang , Xiaojie Song . “Preparation of Carbon Nanotube/SnS₂ Photoanode Materials”: A Comprehensive University Chemistry Experiment. University Chemistry, 2024, 39(4): 157-162. doi: 10.3866/PKU.DXHX202308025
10. [10]
  Xiaochen Zhang , Fei Yu , Jie Ma . 多角度数理模拟在电容去离子中的前沿应用. Acta Physico-Chimica Sinica, 2024, 40(11): 2311026-. doi: 10.3866/PKU.WHXB202311026
11. [11]
  Doudou Qin , Junyang Ding , Chu Liang , Qian Liu , Ligang Feng , Yang Luo , Guangzhi Hu , Jun Luo , Xijun Liu . Addressing Challenges and Enhancing Performance of Manganese-based Cathode Materials in Aqueous Zinc-Ion Batteries. Acta Physico-Chimica Sinica, 2024, 40(10): 2310034-. doi: 10.3866/PKU.WHXB202310034
12. [12]
  Feiya Cao , Qixin Wang , Pu Li , Zhirong Xing , Ziyu Song , Heng Zhang , Zhibin Zhou , Wenfang Feng . Magnesium-Ion Conducting Electrolyte Based on Grignard Reaction: Synthesis and Properties. University Chemistry, 2024, 39(3): 359-368. doi: 10.3866/PKU.DXHX202308094
13. [13]
  Xuyang Wang , Jiapei Zhang , Lirui Zhao , Xiaowen Xu , Guizheng Zou , Bin Zhang . Theoretical Study on the Structure and Stability of Copper-Ammonia Coordination Ions. University Chemistry, 2024, 39(3): 384-389. doi: 10.3866/PKU.DXHX202309065
14. [14]
  Dongqi Cai , Fuping Tian , Zerui Zhao , Yanjuan Zhang , Yue Dai , Feifei Huang , Yu Wang . Exploration of Factors Influencing the Determination of Ion Migration Number by Hittorf Method. University Chemistry, 2024, 39(4): 94-99. doi: 10.3866/PKU.DXHX202310031
15. [15]
  Jiayu Tang , Jichuan Pang , Shaohua Xiao , Xinhua Xu , Meifen Wu . Improvement for Measuring Transference Numbers of Ions by Moving-Boundary Method. University Chemistry, 2024, 39(5): 193-200. doi: 10.3866/PKU.DXHX202311021
16. [16]
  Yifeng Xu , Jiquan Liu , Bin Cui , Yan Li , Gang Xie , Ying Yang . “Xiao Li’s School Adventures: The Working Principles and Safety Risks of Lithium-ion Batteries”. University Chemistry, 2024, 39(9): 259-265. doi: 10.12461/PKU.DXHX202404009
17. [17]
  Wendian XIE , Yuehua LONG , Jianyang XIE , Liqun XING , Shixiong SHE , Yan YANG , Zhihao HUANG . Preparation and ion separation performance of oligoether chains enriched covalent organic framework membrane. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1528-1536. doi: 10.11862/CJIC.20240050
18. [18]
  Xiaoning TANG , Shu XIA , Jie LEI , Xingfu YANG , Qiuyang LUO , Junnan LIU , An XUE . Fluorine-doped MnO₂ with oxygen vacancy for stabilizing Zn-ion batteries. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1671-1678. doi: 10.11862/CJIC.20240149
19. [19]
  Siyu Zhang , Kunhong Gu , Bing'an Lu , Junwei Han , Jiang Zhou . Hydrometallurgical Processes on Recycling of Spent Lithium-lon Battery Cathode: Advances and Applications in Sustainable Technologies. Acta Physico-Chimica Sinica, 2024, 40(10): 2309028-. doi: 10.3866/PKU.WHXB202309028
20. [20]
  Guang Huang , Lei Li , Dingyi Zhang , Xingze Wang , Yugai Huang , Wenhui Liang , Zhifen Guo , Wenmei Jiao . Cobalt’s Valor, Nickel’s Foe: A Comprehensive Chemical Experiment Utilizing a Cobalt-based Imidazolate Framework for Nickel Ion Removal. University Chemistry, 2024, 39(8): 174-183. doi: 10.3866/PKU.DXHX202311051

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(1162)
HTML views(236)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142