Citation: TAI Xi-Shi, ZHAO Wen-Hua, LI Fa-Hui. Synthesis, Crystal Structure and Antitumor Activity of Ca(Ⅱ) Coordination Polymer Constructed by N-Benzenesulphonyl-L-phenylalanine[J]. Chinese Journal of Inorganic Chemistry, ;2013, 29(10): 2200-2204. doi: 10.3969/j.issn.1001-4861.2013.00.272 shu

Synthesis, Crystal Structure and Antitumor Activity of Ca(Ⅱ) Coordination Polymer Constructed by N-Benzenesulphonyl-L-phenylalanine

1.
1 College of Chemistry and Chemical Engineering, Weifang University, Weifang, Shandong 261061, China;

Received Date: 14 November 2012
Available Online: 22 May 2013
Fund Project: 山东省优秀中青年科学家奖励基金(No.2010BSA07004) (No.2010BSA07004)

Colourless crystals of 1Dcoordination polymer, [Ca(L)₂(H₂O)₂(CH₃CH₂OH)]_n(L=N-benzenesulphonyl-L-phenylalanine), were obtained by the reaction of calcium perchlorate and N-benzenesulphonyl-L-phenylalanine in the 95% CH₃CH₂OH solution, and characterized by elemental analysis, IRand X-ray single crystal diffraction analysis. The single-crystal X-ray analysis of the title complex reveals that each Ca(Ⅱ) atom is seven-coordinated in a distorted pentagonal bipyramid coordination environment by seven oxygen atoms from the N-benzenesulphonyl-L-phenylalanine ligand, the coordinated water molecule and the coordinated CH₃CH₂OH molecule, respectively. The molecular structure is 1D coordination polymer by the interaction of bridged carboxylato groups. The antitumor activity against SMMC-7721, A549, WiDr and P388 cancer cells of the Ca(Ⅱ) complex also was investigated. CCDC: 890991.
- N-benzenesulphonyl-L-phenylalanine; Ca(Ⅱ) coordination polymer; synthesis; crystal structure; antitumor activity
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沈阳化工大学材料科学与工程学院沈阳 110142