Citation: ZHU Li-Na, WANG Hai-Xian, SUN Run-Feng, LI Ping, KONG De-Ming, LI Xiao-Zeng. Disruption of G-Quadruplex DNA by Ag⁺ and Hg²⁺ and Its Application to DNA Logic Gate[J]. Chinese Journal of Inorganic Chemistry, ;2013, 29(10): 2215-2224. doi: 10.3969/j.issn.1001-4861.2013.00.259 shu

Disruption of G-Quadruplex DNA by Ag⁺ and Hg²⁺ and Its Application to DNA Logic Gate

1.
1 Department of Chemistry, Tianjin University, Tianjin 300072, China;

Received Date: 1 March 2013
Available Online: 19 April 2013
Fund Project: 国家自然科学基金(No.20801040,21175072)资助项目 (No.20801040,21175072)

The G-quadruplex-disrupting abilities of Ag⁺ and Hg²⁺ ions were investigated by utilizing the metal ions-mediated circular dichroism (CD) spectrum changes of four representative G-quadruplexes. The results show that Ag⁺ ion can disrupt G-quadruplexes by chelating to Gbases and thus can be used as a general G-quadruplex-disrupting agent. The results also suggest that Hg²⁺ ion may disrupt G-quadruplexes by formation of T-Hg²⁺-Tbase pairs as well as other species. The G-quadruplexes disrupted by Ag⁺ and Hg²⁺ can be recovered by cysteine (Cys), a thiol-containing amino acid, due to the tight binding interactions between Cys and the metal ions. Thus, the system by using Ag⁺ (or Hg²⁺) and Cys as two inputs and CDsignal as output can behave as a DNA IMPLICATIONlogic gate.
- G-quadruplex; DNA logic gate; Ag⁺; Hg²⁺; cysteine; circular dichroism
1. [1]
  [1] Gilbert D E, Feigon J. Curr. Opin. Struct. Biol., 1999,9:305- 314 [2] Huppert J L. Chem. Soc. Rev., 2008,37:1375-1384 [3] Williamson J R. Annu. Rev. Biophys. Biomol. Struct., 1994, 23:703-730 [4] Rhodes D, Giraldo R. Curr. Opin. Struct. Biol., 1995,5:311- 322 [5] Zahler A M, Williamson J R, Cech T R, et al. Nature, 1991, 350:718-720 [6] Howell L A, Searcey M. ChemBioChem., 2009,10:2139-2143 [7] Shi S,Yao T M, Ji L N, et al. Dalton Trans., 2012,41:5789- 5793 [8] Shi S,Yao T M,Ji L N, et al. J. Inorg. Biochem., 2013,121:19 -27 [9] Lipps H J, Rhodes D. Trends Cell. Biol., 2009,19:414-422 [10]Neidle S. FEBS J., 2009,277:1118-1125 [11]Shalaby T, Hiyama E, Grotzer M A. Anticancer Agents Med. Chem., 2010,10:196-212 [12]Lechel A, Manns M P, Rudolph K L. J. Hepatol., 2004,41: 491-497 [13]Simonsson T. Biol. Chem., 2001,382:621-628 [14]Gill M L, Strobel S L, Loria J P. Nucleic Acids Res., 2006, 34:4506-4514 [15]Liu W, Liang H J, Fu Y. J. Phys. Chem. B, 2011,115:13051 -13056 [16]Li T, Dong S J, Wang E K. Anal. Chem., 2009,81:2144-2149 [17]Li T, Li B, Wang E K, et al. Chem. Commun., 2009,45: 3551-3553 [18]Zhou X H, Kong D M, Shen H X. Anal. Chem., 2010,82: 789-793 [19]Kong D M, Xu J, Shen H X. Anal. Chem., 2010,82:6148- 6153 [20]Topal S Z, Gürek A G, Ertekin K, et al. Mater. Chem. Phys., 2010,121:425-531 [21]Chen X, Wang Y, Liu Q, et al. Angew. Chem. Int. Ed. Engl., 2006,45:1759-1762 [22]Xie W Y, Huang W T, Li N B, et al. Chem. Commun., 2012,48:82-84 [23]Paramasivan S, Rujan I, Bolton P H. Methods, 2007,43:324- 331 [24]Kong D M, Cai L L, Guo J H, et al. Biopolymers, 2009,91: 331-339 [25]Monchaud D, Yang P, Lacroix L, et al. Angew. Chem. Int. Ed. Engl., 2008,47:4858-4861 [26]Ambrus A, Chen D, Dai J, et al. Nucleic Acids Res., 2006, 34:2723-2735 [27]Kong D M, Ma Y E, Guo J H, et al. Anal. Chem., 2009,81: 2678-2684 [28]Luu K N, Phan A T, Kuryavyi V, et al. J. Am. Chem. Soc., 2006,128:9963-9970 [29]Malumbres M, Barbacid M. Nat. Rev. Cancer, 2003,3:459- 465 [30]Xodo L, Paramasivam M, Membrino A, et al. Nucleic Acids Symp. Ser., 2008,52:159-160 [31]Chen Z, Zheng K W, Hao Y H, et al. J. Am. Chem. Soc., 2009,131:10430-10438 [32]Paramasivam M, Membrino A, Cogoi S, et al. Nucleic Acids Res., 2009,37:2841-2853 [33]Hotary K, Li X Y, Allen E, et al. Genes Dev., 2006,20:2673 -2686 [34]Morris M J, Basu S. Biochem., 2009,48:5313-5319 [35]Gruen L C. Biochim. Biophys. Acta, 1975,386:270-274 [36]Burstein Y, Sperling R. Biochim. Biophys. Acta, 1970,211: 410-412 [37]Guo J H, Kong D M, Shen H X. Biosens. Bioelectron., 2010,26:327-332 [38]Li T, Shi L L, Wang E K, et al. Chem. Eur. J., 2009,15: 3347-3350 [39]Ruan Y B, Li A F, Zhao J S, et al. Chem. Commun., 2010, 46:4938-4940 [40]Jia S M, Liu X F, Li P, et al. Biosens. Bioelectron., 2011, 27:148-152 [41]D'Urso A, Mammana A, Balaz M, et al. J. Am. Chem. Soc., 2009,131:2046-2047 [42]Zhou Y C, Zhang D Q, Zhang Y Z, et al. J. Org. Chem., 2005,70:6164-6170
1. [1]
  Yuhao SUN , Qingzhe DONG , Lei ZHAO , Xiaodan JIANG , Hailing GUO , Xianglong MENG , Yongmei GUO . Synthesis and antibacterial properties of silver-loaded sod-based zeolite. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 761-770. doi: 10.11862/CJIC.20230169
2. [2]
  Wendian XIE , Yuehua LONG , Jianyang XIE , Liqun XING , Shixiong SHE , Yan YANG , Zhihao HUANG . Preparation and ion separation performance of oligoether chains enriched covalent organic framework membrane. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1528-1536. doi: 10.11862/CJIC.20240050
3. [3]
  Yingran Liang , Fei Wang , Jiabao Sun , Hongtao Zheng , Zhenli Zhu . Construction and Application of a New Experimental Device for Determination of Alkaline Metal Elements by Plasma Atomic Emission Spectrometry Based on Solution Cathode Glow Discharge: An Alternative Approach for Fundamental Teaching Experiments in Emission Spectroscopy. University Chemistry, 2024, 39(5): 380-387. doi: 10.3866/PKU.DXHX202312024
4. [4]
  Xiaoning TANG , Shu XIA , Jie LEI , Xingfu YANG , Qiuyang LUO , Junnan LIU , An XUE . Fluorine-doped MnO₂ with oxygen vacancy for stabilizing Zn-ion batteries. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1671-1678. doi: 10.11862/CJIC.20240149
5. [5]
  Wenjun Zheng . Application in Inorganic Synthesis of Ionic Liquids. University Chemistry, 2024, 39(8): 163-168. doi: 10.3866/PKU.DXHX202401020
6. [6]
  Kexin Dong , Chuqi Shen , Ruyu Yan , Yanping Liu , Chunqiang Zhuang , Shijie Li . Integration of Plasmonic Effect and S-Scheme Heterojunction into Ag/Ag₃PO₄/C₃N₅ Photocatalyst for Boosted Photocatalytic Levofloxacin Degradation. Acta Physico-Chimica Sinica, 2024, 40(10): 2310013-. doi: 10.3866/PKU.WHXB202310013
7. [7]
  Hongyun Liu , Jiarun Li , Xinyi Li , Zhe Liu , Jiaxuan Li , Cong Xiao . Course Ideological and Political Design of a Comprehensive Chemistry Experiment: Constructing a Visual Molecular Logic System Based on Intelligent Hydrogel Film Electrodes. University Chemistry, 2024, 39(2): 227-233. doi: 10.3866/PKU.DXHX202309070
8. [8]
  Hong LI , Xiaoying DING , Cihang LIU , Jinghan ZHANG , Yanying RAO . Detection of iron and copper ions based on gold nanorod etching colorimetry. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 953-962. doi: 10.11862/CJIC.20230370
9. [9]
  Xiaochen Zhang , Fei Yu , Jie Ma . 多角度数理模拟在电容去离子中的前沿应用. Acta Physico-Chimica Sinica, 2024, 40(11): 2311026-. doi: 10.3866/PKU.WHXB202311026
10. [10]
  Rui Li , Huan Liu , Yinan Jiao , Shengjian Qin , Jie Meng , Jiayu Song , Rongrong Yan , Hang Su , Hengbin Chen , Zixuan Shang , Jinjin Zhao . 卤化物钙钛矿的单双向离子迁移. Acta Physico-Chimica Sinica, 2024, 40(11): 2311011-. doi: 10.3866/PKU.WHXB202311011
11. [11]
  Doudou Qin , Junyang Ding , Chu Liang , Qian Liu , Ligang Feng , Yang Luo , Guangzhi Hu , Jun Luo , Xijun Liu . Addressing Challenges and Enhancing Performance of Manganese-based Cathode Materials in Aqueous Zinc-Ion Batteries. Acta Physico-Chimica Sinica, 2024, 40(10): 2310034-. doi: 10.3866/PKU.WHXB202310034
12. [12]
  Feiya Cao , Qixin Wang , Pu Li , Zhirong Xing , Ziyu Song , Heng Zhang , Zhibin Zhou , Wenfang Feng . Magnesium-Ion Conducting Electrolyte Based on Grignard Reaction: Synthesis and Properties. University Chemistry, 2024, 39(3): 359-368. doi: 10.3866/PKU.DXHX202308094
13. [13]
  Xuyang Wang , Jiapei Zhang , Lirui Zhao , Xiaowen Xu , Guizheng Zou , Bin Zhang . Theoretical Study on the Structure and Stability of Copper-Ammonia Coordination Ions. University Chemistry, 2024, 39(3): 384-389. doi: 10.3866/PKU.DXHX202309065
14. [14]
  Dongqi Cai , Fuping Tian , Zerui Zhao , Yanjuan Zhang , Yue Dai , Feifei Huang , Yu Wang . Exploration of Factors Influencing the Determination of Ion Migration Number by Hittorf Method. University Chemistry, 2024, 39(4): 94-99. doi: 10.3866/PKU.DXHX202310031
15. [15]
  Jiayu Tang , Jichuan Pang , Shaohua Xiao , Xinhua Xu , Meifen Wu . Improvement for Measuring Transference Numbers of Ions by Moving-Boundary Method. University Chemistry, 2024, 39(5): 193-200. doi: 10.3866/PKU.DXHX202311021
16. [16]
  Yifeng Xu , Jiquan Liu , Bin Cui , Yan Li , Gang Xie , Ying Yang . “Xiao Li’s School Adventures: The Working Principles and Safety Risks of Lithium-ion Batteries”. University Chemistry, 2024, 39(9): 259-265. doi: 10.12461/PKU.DXHX202404009
17. [17]
  Peiran ZHAO , Yuqian LIU , Cheng HE , Chunying DUAN . A functionalized Eu³⁺ metal-organic framework for selective fluorescent detection of pyrene. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 713-724. doi: 10.11862/CJIC.20230355
18. [18]
  Qingtang ZHANG , Xiaoyu WU , Zheng WANG , Xiaomei WANG . Performance of nano Li₂FeSiO₄/C cathode material co-doped by potassium and chlorine ions. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1689-1696. doi: 10.11862/CJIC.20240115
19. [19]
  Siyu Zhang , Kunhong Gu , Bing'an Lu , Junwei Han , Jiang Zhou . Hydrometallurgical Processes on Recycling of Spent Lithium-lon Battery Cathode: Advances and Applications in Sustainable Technologies. Acta Physico-Chimica Sinica, 2024, 40(10): 2309028-. doi: 10.3866/PKU.WHXB202309028
20. [20]
  Qi Li , Pingan Li , Zetong Liu , Jiahui Zhang , Hao Zhang , Weilai Yu , Xianluo Hu . Fabricating Micro/Nanostructured Separators and Electrode Materials by Coaxial Electrospinning for Lithium-Ion Batteries: From Fundamentals to Applications. Acta Physico-Chimica Sinica, 2024, 40(10): 2311030-. doi: 10.3866/PKU.WHXB202311030

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(271)
HTML views(9)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Disruption of G-Quadruplex DNA by Ag+ and Hg2+ and Its Application to DNA Logic Gate

Metrics

通讯作者: 陈斌, bchen63@163.com

Disruption of G-Quadruplex DNA by Ag⁺ and Hg²⁺ and Its Application to DNA Logic Gate