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Citation: KONG Liang, FENG Xiue, GAO Jie, LI Jing, LI Qingshan. Synthesis of Novel Phenyl(thiophen-2-yl) methanone Derivatives and Their Cytoprotective Activities Against H₂O₂-induced Injury in Human Umbilical Vein Endothelial Cells[J]. Chinese Journal of Applied Chemistry, ;2014, 31(10): 1185-1190. doi: 10.3724/SP.J.1095.2014.30651 shu

Synthesis of Novel Phenyl(thiophen-2-yl) methanone Derivatives and Their Cytoprotective Activities Against H₂O₂-induced Injury in Human Umbilical Vein Endothelial Cells

1.
School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China

Corresponding author: FENG Xiue, LI Qingshan,
Received Date: 23 December 2013
Available Online: 6 March 2014
Fund Project: 国家"863"计划项目(2013AA092903) (2013AA092903)山西省自然科学基金资助项目(2013011060-2) (2013011060-2)山西医科大学科技创新基金资助项目(01201116) (01201116)山西医科大学博士启动基金资助项目(B03201213) (B03201213)山西省高等学校大学生创新创业训练项目(2013116) (2013116)

Thirteen phenyl(thiophen-2-yl) methanone derivatives were designed and synthesized by classic synthetic methods, in which compounds 9b, 10b and 11b are new. All target structures were confirmed by ESI-MS, ¹H NMR and ¹³C NMR. Their in vitro cytoprotective activities against H₂O₂-induced injury on human umbilical vein endothelial cells(HUVECs) were tested. And the results show that p-methoxy groups and two chlorine atoms substituted on the phenyl ring express preferable protective activity. The preliminary structureactivity relationships results show that the position, number and type of substituents on the core structure have remarkable effects on protective activities against H₂O₂-induced injury on HUVECs.
- phenyl(thiophen-yl) methanone,
- synthesis,
- human umbilical vein endothelial cells,
- cytoprotective activity
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Synthesis of Novel Phenyl(thiophen-2-yl) methanone Derivatives and Their Cytoprotective Activities Against H2O2-induced Injury in Human Umbilical Vein Endothelial Cells

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通讯作者: 陈斌, bchen63@163.com

Synthesis of Novel Phenyl(thiophen-2-yl) methanone Derivatives and Their Cytoprotective Activities Against H₂O₂-induced Injury in Human Umbilical Vein Endothelial Cells