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Citation: GOU Gaozhang, WU Na, SHI Ling, XU Shijuan, YAN Heping, LIU Wei. Bromination of 2-Methyl-1,8-naphthyridine Derivatives[J]. Chinese Journal of Applied Chemistry, ;2014, 31(11): 1268-1272. doi: 10.3724/SP.J.1095.2014.30642 shu

Bromination of 2-Methyl-1,8-naphthyridine Derivatives

GOU Gaozhang ^a,b ,
WU Na ^a,b ,
SHI Ling ^a,b ,
XU Shijuan ^a,b ,
YAN Heping ^a,b ,
LIU Wei ^a,b,,

1.
a College of Science, Honghe University, Mengzi 661100, China;
2.
b Key Laboratory of Natural Pharmaceutical & Chemical Biology of Yunnan Province, Honghe University, Mengzi 661100, China

Corresponding author: LIU Wei,
Received Date: 18 December 2013
Available Online: 4 May 2014
Fund Project: 国家自然科学基金资助项目(61361002) (61361002)云南省应用基础研究计划自筹项目(2013FZ121) (2013FZ121)云南省化学硕士点建设学科资助项目(HXZ1303) (HXZ1303)

This paper reported the bromination of 2-methyl-1,8-naphthyridine derivatives.Monobrominated products,2-bromomethyl-1,8-naphthyridine derivatives,and dibrominated byproducts were obtained with N-bromosuccimide(NBS) as the bromination agent under infrared light.Two synthetic conditions were evaluated.The yield of monobrominated products is up to 54.6% under the optimized condition of 2-methyl-1,8-naphthyrdine derivatives and NBS in molar ratio of 1:1.2 under 500 W infrared light.
- naphthyridine,
- N-bromosuccinimide,
- initiator
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