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Citation: ZHANG Zhijian, KUANG Daizhi, ZHANG Fuxing, YU Jiangxi, JIANG Wujiu. Synthesis,Crystal Structure and Biological Activities of the Tris(2-methyl-2-phenyl) propyl Tin Trichloroacetic Acid Ester[J]. Chinese Journal of Applied Chemistry, ;2014, 31(9): 1058-1062. doi: 10.3724/SP.J.1095.2014.30517 shu

Synthesis,Crystal Structure and Biological Activities of the Tris(2-methyl-2-phenyl) propyl Tin Trichloroacetic Acid Ester

1.
a Department of Life Sciences, Hengyang Normal University, Hengyang 421008, China;
2.
b Department of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, China

Corresponding author: ZHANG Zhijian,
Received Date: 17 October 2013
Available Online: 17 February 2014
Fund Project: 湖南省科技计划项目一般项目资助(2014FJ3060) (2014FJ3060)湖南省重点建设学科和重点实验室资助项目(13K03,13K04,13K05) (13K03,13K04,13K05)

The title complex, tris(2-methyl-2-phenyl) propyl tin trichloroacetic acid ester(CCDC:932139), was synthesized by the reaction of bis[tris(2-methyl-2-phenyl) propyl]tin oxide with trichloroacetic acid and characterized by IR, ¹H NMR spectroscopy and elemental analysis, respectively. The crystal structure was determined by X-ray diffraction to be monoclinic with a P2₁/n space group with a=1.1186(4) nm, b=1.8366(7) nm, c=1.6020(6) nm, α=90°, β=91.316(10) °, γ=90°, V=3.2902(19) nm³, Z=4, D_c=1.374 g/cm³, μ(MoKα)=1.046 mm^-1, F(000)=1392, and R₁=0.0589, wR₂=0.1619. The crystal structure shows that the central Sn atom is four-coordinated to assume a distorted tetrahedral configuration. Bioassay results show that the complex displays good in vitro antitumor activities against five human tumor cell lines, HT-29, HepG-2, MCF-7, KB and A549, and has selective antibacterial property.
- organotin carboxylates,
- synthesis,
- crystal structure,
- in vitro antitumor activity,
- antibacterial activity
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