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Citation: KE Fang, WU Wen, LI Peng, LIN Chen. Microwave-assisted Synthesis of Benzothiazole Derivatives in Aqueous Solution[J]. Chinese Journal of Applied Chemistry, ;2014, 31(6): 721-725. doi: 10.3724/SP.J.1095.2014.30357 shu

Microwave-assisted Synthesis of Benzothiazole Derivatives in Aqueous Solution

KE Fang ^a,, ,
WU Wen ^b ,
LI Peng ^a ,
LIN Chen ^a

1.
a Department of Pharmacy, Fujian Medical University, Fuzhou 350004, China;
2.
b Xiamen Maternity and Child care Hospital, Xiamen 361003, China

Corresponding author: KE Fang,
Received Date: 17 July 2013
Available Online: 3 September 2013
Fund Project: 国家自然科学基金资助项目(81202560) (81202560)福建省自然科学基金资助项目(2012J05150) (2012J05150)

A novel protocol,efficient,inexpensive for the microwave-assisted copper-catalyzed synthesis of benzothiazoles derivatives through the reaction of 2-iodoanilines with aldehydes and KSCN in aqueous solution was investigated.The reactions was catalyzed by a combination of CuI and 1,10-phenanthroline with Cs₂CO₃ as a base and in neat water at 100℃ for 30 min.A variety of benzothiazoles can be synthesized in an excellent yield up to 94%.
- microwave-assisted synthesis,
- iodoaniline,
- aldehyde,
- benzothiazole
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