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Citation: DUAN Zhengchao, WANG Lianzhi, ZUO Xiaoyu, QU Taoli, HU Xiangping, ZHENG Zhuo. Rh-catalyzed Asymmetric Hydrogenation of β,γ-Unsaturated Phosphonates with WalPhos Ligands[J]. Chinese Journal of Applied Chemistry, ;2014, 31(2): 242-244. doi: 10.3724/SP.J.1095.2014.30194 shu

Rh-catalyzed Asymmetric Hydrogenation of β,γ-Unsaturated Phosphonates with WalPhos Ligands

1.
a Hubei University for Nationalities, Enshi 445000, China;
2.
b Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China

Corresponding author: DUAN Zhengchao, HU Xiangping,
Received Date: 22 April 2013
Available Online: 24 May 2013
Fund Project: 国家自然科学基金项目(21262011) (21262011)教育部重点项目(211111)资助 (211111)

An enantioselective synthesis of chiral alkylphosphonates bearing a β-stereogenic center,based on the Rh-catalyzed asymmetric hydrogenation of corresponding β-substituted β,γ-unsaturated phosphonates with(R_c,S_p)-WalPhos ligand under the mild hydrogenation conditions(1.0 MPa hydrogen pressure and room temperature),was developed.The full conversions can be achieved and an ee value of up to 87% is obtained.
- β-substituted β,
- γ-unsaturated phosphonates,
- asymmetric catalytic hydrogenation,
- rhodium,
- chiral β-aryl-substituted propylphosphonates
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