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Citation: HONG Tao, WANG Qiuyun, FAN Jun, CHEN Wenjing, ZHENG Shengrun, ZHANG Weiguang. Chiral Recognition of Mandelic Acid with Bovine and Goat Serum Albumins by Flow Injection Analysis-Quartz Crystal Microbalance[J]. Chinese Journal of Applied Chemistry, ;2013, 30(9): 1096-1098. doi: 10.3724/SP.J.1095.2013.30012 shu

Chiral Recognition of Mandelic Acid with Bovine and Goat Serum Albumins by Flow Injection Analysis-Quartz Crystal Microbalance

School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China

Received Date: 7 January 2013
Revised Date: 21 February 2013

Interactions of mandelic acid(MA) and bovine/goat serum albumins(BSA/GSA) have been investigated by FIA-QCM and UV-Vis spectroscopy, respectively. Based on frequency shift of quartz crystal,surface concentrations of immobilized BSA and GSA were 4.9 × 10^-12 and 8.8 × 10^-12 mol/cm²,respectively. After injecting mandelic acid into FIA-QCM system,frequency of the quartz crystal decreases due to interactions between enantiomers and SA molecules and the shifts between SA and R-MA are greater than those with S-enantiomer,indicating that the interactions of SA molecules with R-MA are stronger than those with S-MA. The UV binding constants for SA with S-MA are smaller than those with R-enantiomer. Taking into account the discrimination factors (α_QCM and α_UV),GSA shows a better chiral recognition with mandelic acid than BSA.
- serum albumin,
- mandelic acid,
- flow injection analysis-quartz crystal microbalance,
- UV-Vis spectroscopy,
- discrimination factor
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