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Citation: HUANG Lirong, CHEN Lei, YANG Xiaosheng, MA Lin, ZHANG Jianxin, WANG Daoping. Synthesis and Antitumor Activity of 2β-Hydroxyursolic Acid[J]. Chinese Journal of Applied Chemistry, ;2013, 30(10): 1133-1138. doi: 10.3724/SP.J.1095.2013.20561 shu

Synthesis and Antitumor Activity of 2β-Hydroxyursolic Acid

a. Ministry of Education Key Laboratory of Green Pesticide and Ago-Bioengineering, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang 550025, China;
b. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China

Received Date: 3 December 2012
Revised Date: 14 January 2013

Using ursolic acid as the precursor,2β-hydroxyursolic acid was synthesized by 6-step successive reactions including oxidation,benzylation,acetylation,hydrolysis,reduction,and group deprotection reactions. The overall yield is 60.1%. Its structure was determined by IR,¹H NMR,¹³C NMR and MS. The antitumor activity of the target compound was evaluated against the proliferation of human leukemia cell K562 and human lung carcinoma cell A549 by the MTT assay. The results indicate that the target compound has inhibitive activity toward cell growth for the two tumor cells.
- ursolic acid,
- 2β-hydroxyursolic acid,
- synthesis,
- inhibition activity to tumor cell
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