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Citation: ZHANG Yaozhou, XIAO Ying, YANG Junjie, HU Guoqiang. Synthesis and Antitumor Activity of Oxime Ether Thiadiazolylthioethers[J]. Chinese Journal of Applied Chemistry, ;2013, 30(4): 383-388. doi: 10.3724/SP.J.1095.2013.20259 shu

Synthesis and Antitumor Activity of Oxime Ether Thiadiazolylthioethers

a. Department of Biotechnology, Xinyang Agricultural College, Xinyang 464000, China;
b. Institute of Chemistry & Biology, Henan University, Kaifeng 475001, China

Received Date: 11 June 2012
Revised Date: 13 August 2012

The synthesis of six oxime ether thiadiazolylthioether compounds(4a-4f) involved a β-chloropropiophenone substitution on 2-mercapto-5-substituded-1,3,4-thiadiazole,oximation with hydroxylamine and etherification with 5-chloromethyl-2-phenyl-1,3,4-oxadiazole.Their structures were characterized by ¹H NMR,IR,MS and elemental analysis.The in vitro antitumor activities of the six compounds to B16,HL60 and SMMC-7721 cancer cell strains were evaluated by MTT assay.The preliminary results showed that some of them showed potential antiproliferation activity.
- thiadiazole,
- oxadiazole,
- oxime ether,
- antitumor activity
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