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Citation: ZHANG Min, ZHOU Shang, ZHU Qianhua, YANG Qiong, YANG Jidong. Resonance Rayleigh Scattering Spectra of α₁-Receptor Blocker Drugs and Some Isopoly Acids and Their Analytical Applications[J]. Chinese Journal of Applied Chemistry, ;2013, 30(3): 335-342. doi: 10.3724/SP.J.1095.2013.20206 shu

Resonance Rayleigh Scattering Spectra of α₁-Receptor Blocker Drugs and Some Isopoly Acids and Their Analytical Applications

ZHANG Min ^a, ,
ZHOU Shang ^b ,
ZHU Qianhua ^b ,
YANG Qiong ^b ,
YANG Jidong ^a,c

a. School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China;
b. School of Chemistry and Chemical Engineering, Yangtze Normal University, Chongqing 408100, China;
c. School of Chemical and Environmental Engineering, Three Gorges Univeisity, Chongqing 404100, China

Received Date: 17 May 2012
Revised Date: 28 June 2012

In an acid solution,an isopoly-acid anion such as isopoly-molybdic acid or isopoly-tungstic acid could react with prazosin hydrochloride(PRH) and doxazosin mesyllate(Dox) α₁-receptor blocker drugs to form ion-association complexes respectively. It resulted in the great enhancement of resonance Rayleigh scattering(RRS) intensities and new RRS peaks. The maximum RRS wavelength was located at 367 nm for isopoly-molybdic acid system and 290 nm for isopoly-tungstic acid system. The reaction products of the two drugs had similar spectral characteristics.The optimum pH ranges were 2.1-2.3 for isopoly-molybdic acid-PRH system and 3.1-3.3 for isopoly-tungstic acid-PRH system.In a certain range,the intensities of RRS were directly proportional to the concentration of drugs for the two different reaction systems.The reactions exhibited a high sensitivity,with a detection limit(3σ/s) of 4.76 μg/L (isopoly-molybdic acid-PRH system) and 9.88 μg/L (isopoly-tungstic acid-PRH system) for PRH,and also showed a good selectivity. The method was applied to the determination of α₁-receptor blocker drugs in tablets and human urine samples. Density functional theory(DFT) calculations with Gaussian 03W at B3LYP/6-31G level were performed to calculate the charge distribution of PRH for investigating the reaction mechanism; in addition,the reasons for the RRS enhancement of the system were discussed.
- prazosin hydrochloride,
- doxazosin mesyllate,
- resonance Rayleigh scattering,
- molybdate,
- tungstate
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Resonance Rayleigh Scattering Spectra of α₁-Receptor Blocker Drugs and Some Isopoly Acids and Their Analytical Applications