Citation:
GUO Wenyan, ZHAO Minggang, HAO Aiyou. Synthesis of Amphiphilic β-Cyclodextrins and Their Nanospheres in Water[J]. Chinese Journal of Applied Chemistry,
;2013, 30(3): 260-264.
doi:
10.3724/SP.J.1095.2013.20164
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Four amphiphilic bifunctionalized β-cyclodextrin derivatives with low degree of substitution(DS) were conveniently synthesized via the reaction of 2-O-(2-hydroxypropyl)-β-cyclodextrin with Lauryl glycidol ether,tetradecyl glycidol ether,hexadecyl glycidol ether and octadecyl glycidol ether in pyridine,respectively.The four amphiphilic β-CD derivatives(DS 1.87,1.95,2.14 and 1.80,respectively) could self-assemble in water to form stable nanospheres with improved dispersion degree and uniformity up to 2~3 weeks.
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