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Citation: ZHANG Huichen, CHEN Xiaojun, WANG Lixia, ZHAO Zhen, LIN Fangqin, GUAN Shiyou. High Efficient Synthesis of 1-Azabicyclo[2.2.2] octane[J]. Chinese Journal of Applied Chemistry, ;2012, 29(12): 1468-1470. doi: 10.3724/SP.J.1095.2012.20014 shu

High Efficient Synthesis of 1-Azabicyclo[2.2.2] octane

1.
a School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China;
2.
b Guangzhou Tinci Materials Technology Co., Ltd., Guangzhou 510760, China

Corresponding author: GUAN Shiyou,
Received Date: 12 January 2012
Available Online: 19 March 2012
Fund Project: 国家自然科学基金(20973060) (20973060)上海市浦江人才计划(09PJ1403400)资助项目 (09PJ1403400)

1-Azabicyclo[2.2.2]octane(quinuclidine) was obtained via the direct intramolecular dehydration reaction of 4-(2-hydroxyethyl) piperidine vapor in presence of CNM-3,a solid acidic catalyst.The yield of quinuclidine can reach 76.8% at 425℃ for 4 h with the highest yield up to 84.3%.Due to the easy accessible of the precursors,the established method is believed to be promising for the scale-up of quinuclidine.
- azabicyclo[2.2.2]octane,
- quinuclidine,
- high effect synthesis,
- (hydroxyethyl) piperidine,
- solid acidic catalyst
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