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Citation: CHEN Xiuying, GUO Lin, ZHENG Changge, GAO Haiyan, AN Wen. Synthesis and Spectral Properties of Benzothiazole Cyanine Dyes for Nucleic Acid Fluorescence Probe[J]. Chinese Journal of Applied Chemistry, ;2012, 29(8): 892-897. doi: 10.3724/SP.J.1095.2012.00441 shu

Synthesis and Spectral Properties of Benzothiazole Cyanine Dyes for Nucleic Acid Fluorescence Probe

1.
School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China

Corresponding author: CHEN Xiuying,
Received Date: 30 September 2011
Available Online: 25 November 2011
Fund Project: 国家自然科学基金(20706026)资助项目 (20706026)中央高校基本科研业务费专项资金(JUSRP211A12,JUSRP21110) (JUSRP211A12,JUSRP21110)

Three novel asymmetric trimethine benzothiazole cyanine dyes with different N-substituents were designed and synthesized.The structures of the dyes were characterized,and the maximums of the spectral absorption and emission of the dyes in ethanol were found in the range of 629~635 nm and 656~672 nm.The Stokes shift values for dyes 8,9 and 10 were 23,37 and 27 nm,respectively.The dyes were almost non-fluorescent in solvents with a low fluorescent quantum yield of less than 0.021 in ethanol,which could reduce the background interference greatly.The photodegradation experiment showed that the introduction of benzyl group on the heteroaromatic rings improved the photostabilites of the dyes obviously.The oxidizing potentials for the dyes 8,9 and 10 were at 0.535,0.456 and 0.399 V vs SCE,which was consistent with the data of photodegradation experiment.
- benzothiazole cyanine dye,
- nucleic acid probe,
- photodegradation,
- cyclic voltammetry,
- disease diagnosis
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