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Citation: LI Shangde, WEI Meiyan, LI Zhihua, SHE Zhigang, LIN Yongcheng. Isolation and Structure Elucidation of Secondary Metabolites from Mangrove Endophytic Fungus Penicillium sp.(ZZF29#)[J]. Chinese Journal of Applied Chemistry, ;2012, 29(6): 727-729. doi: 10.3724/SP.J.1095.2012.00438 shu

Isolation and Structure Elucidation of Secondary Metabolites from Mangrove Endophytic Fungus Penicillium sp.(ZZF29#)

1.
a School of Pharmacy, Guangdong Medical College, Dongguan 523808, China;
2.
b School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China

Corresponding author: LI Shangde,
Received Date: 28 September 2011
Available Online: 6 March 2012
Fund Project: 湛江市科技攻关计划项目(2009C3106011) (2009C3106011)广东医学院面上基金资助项目(M2010002) (M2010002)

The secondary metabolites of the medicinal mangrove endophytic fungus Penicillium sp.(ZZF29#) were firstly studied.Eight compounds were isolated from the ethyl acetate extract of the fermentation using silica gel column chromatography,preparative thin-layer chromatography and recrystallization.The structures of the compounds were identified as cyclo-(Phe-Ala)(1),cyclo-(Phe-Gly)(2),cyclo-(Phe-Phe)(3),cyclo-(Phe-Tyr)(4),emodin(5),physcion(6),ergosterol(7) and peroxide ergosterol(8),by comprehensive spectroscopic characterizations as well as comparison with reported data.
- mangrove endophytic fungus,
- Penicillium sp.(ZZF29#),
- secondary metabolites,
- isolation and elucidation,
- cyclodipeptides,
- anthraquinones,
- sterols
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