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Citation: TANG Zilong, CHANG Shuhong, YAN Lin, LIU Hanwen. Synthesis and Fungicidal Activity of 2-(1, 3, 4-Thiadiazolylaminomethyl)phenols[J]. Chinese Journal of Applied Chemistry, ;2012, 29(8): 878-884. doi: 10.3724/SP.J.1095.2012.00410 shu

Synthesis and Fungicidal Activity of 2-(1, 3, 4-Thiadiazolylaminomethyl)phenols

TANG Zilong ^a,b,, ,
CHANG Shuhong ^b,c ,
YAN Lin ^b ,
LIU Hanwen ^a,b

1.
a Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan University of Science and Technology, Xiangtan 411201, China;
2.
b School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Hunan University of Science and Technology, Xiangtan 411201, China;
3.
c Jiangxi Dongbang Pharmaceutical Co. Ltd., Fengxin 330700, China

Corresponding author: TANG Zilong,
Received Date: 13 September 2011
Available Online: 28 November 2011
Fund Project: 国家自然科学基金(21042011)资助项目 (21042011)湖南省教育厅重点项目(10A034) (10A034)湖南省博士后基金课题(2010RS4033) (2010RS4033)

A series of 2-(1,3,4-thiadiazolylaminomethyl)phenols was synthesized by reducing the C=N double bond of the intermediate Schiff bases prepared from the reaction of 2-amino-5-alkyl(aryl)-1,3,4-thiadiazoles and salicylaldehyde via either fractional step method or one-pot process.The yields of the products obtained from one-pot synthesis were higher and in the range of 56%~80%.The structures of the products were characterized by means of IR,¹H NMR,¹³C NMR and MS.The fungicidal activity of the title compounds was evaluated preliminarily,some of which exhibited moderate activity against Alternaria alternata.The inhibitory rate of compound 3i was 76% at the concentration of 25 mg/L,and 70% for compounds 3f,3h,3k and 3l.
- thiadiazolylaminomethylphenol,
- synthesis,
- fungicidal activity
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