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Citation: HU Shuaishuai, GUO Haichang, JIANG Huajiang, ZHENG Renhua. N-Arylation of Nitrogen Heterocycles Catalyzed by Copper(Ⅰ) Iodide/Ethylenediamine[J]. Chinese Journal of Applied Chemistry, ;2011, 28(10): 1179-1183. doi: 10.3724/SP.J.1095.2011.00647 shu

N-Arylation of Nitrogen Heterocycles Catalyzed by Copper(Ⅰ) Iodide/Ethylenediamine

1.
School of Pharmaceutical and Chemical Engineering of Taizhou University, Linhai 317000

Corresponding author: GUO Haichang,
Received Date: 1 November 2010
Available Online: 31 December 2010

This paper discussed the Ullmann reaction of aryl halides with nitrogen heterocycles catalyzed by copper(Ⅰ) iodide/ethylenediamine.The results showed that reaction was preferred for nitrogen heterocycles with lower pK_a values.In addition,the reactions were also favorable for the electron-rich aryl halides with p-π conjugations,however,they became difficult for other electron-rich aryl halides.
- Ullmann reaction,
- N-arylation reaction,
- nitrogen heterocycles,
- copper(Ⅰ) iodide/ethylenediamine catalyst
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