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Citation: ZHAO Dishun, LV Bin, KOU Cheng, YANG Jie, DONG Lanfen, ZHANG Yan. Measurement of Crystallization Metastable Zone of Nitazoxanide Using the Laser Scattering Method[J]. Chinese Journal of Applied Chemistry, ;2011, 28(9): 1063-1066. doi: 10.3724/SP.J.1095.2011.00610 shu

Measurement of Crystallization Metastable Zone of Nitazoxanide Using the Laser Scattering Method

ZHAO Dishun ^a,, ,
LV Bin ^b ,
KOU Cheng ^a ,
YANG Jie ^a ,
DONG Lanfen ^a ,
ZHANG Yan ^a

1.
a College of Chemistry and Pharmaceutical Engineering, Shijiazhuang 050018;
2.
b College of Sciences, Hebei University of Science and Technology, Shijiazhuang 050018

Corresponding author: ZHAO Dishun,
Received Date: 13 October 2010
Available Online: 25 December 2010

The saturated and supersaturated characteristics of nitazoxanide in DMF, DMSO, methanol and acetone at different temperatures were investigated by using the laser detection technique. The crystallization metastable zone widths of nitazoxanide were obtained at different temperatures in the above four solvents. The results indicated that the solubility, supersolubility and the metastable zone width of nitazoxanide enhance with increasing temperature. At the same temperature, the metastable zone width of nitazoxanide relations as follows:acetone< DMSO< methanol< DMF.
- nitazoxanide,
- solubility,
- supersolubility,
- metastable zone width
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