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Citation: LI Yang, LU Junrui, XIN Chunwei, LIU Qian, BAO Xiurong, LI Kaixia. Synthesis,Characterization and Antibacterial Activities of N-(5-Chloro-2-hydroxyphenyl) Amino Acid Derivatives and Their Metal Complexes[J]. Chinese Journal of Applied Chemistry, ;2011, 28(6): 645-651. doi: 10.3724/SP.J.1095.2011.00502 shu

Synthesis,Characterization and Antibacterial Activities of N-(5-Chloro-2-hydroxyphenyl) Amino Acid Derivatives and Their Metal Complexes

1.
College of Chemistry and Chemical Engineering, Tianjin Univercity of Technology, Tianjin 300384

Corresponding author: LU Junrui,
Received Date: 27 August 2010
Available Online: 31 October 2010
Fund Project: 国家自然科学基金(20976135,20776114) (20976135,20776114)天津市高校科技发展基金(2006ZD33)资助项目 (2006ZD33)

In order to find more stable and effective antibacterial compounds,we screened some N-(5-chloro-2-hydroxybenzyl) amino acid ester with good antibacterial activities.Twenty metal-amino complexes with 1:1 molar ratio of ligand to metal cation were synthesized via a step-by-step method in alkaline aqueous solutions or water-methanol mixed solvents at room temperature.These complexes and the structures of the compounds were confirmed by ¹H NMR,IR and UV.It was found that the hydroxyl group,amine group and carboxyl group of ligands could coordinate with metal cations.Preliminary bioassay results showed that nearly all the metal complexes have better anti-bacteria activities than their counterpart ligands,especially for the Monilia albicans which has a 100% inhibitory ratio.The conditions of the preparation of N-(5-chloro-2-hydroxyphenyl) amino acid ester schiff-base were optimized.
- N-(chlorohydroxylbenzyl) amino acid/ester,
- complex,
- antibacterial property
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