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Citation: LI Hongfei, ZHANG Liangze, WU Dingming, MU Weining, ZHOU Juntao. Synthesis of 6-Chlorin-8-alkyl-9-aryl-purine Derivatives[J]. Chinese Journal of Applied Chemistry, ;2011, 28(7): 747-752. doi: 10.3724/SP.J.1095.2011.00496 shu

Synthesis of 6-Chlorin-8-alkyl-9-aryl-purine Derivatives

1.
School of Material Science and Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003

Corresponding author: LI Hongfei,
Received Date: 25 August 2010
Available Online: 5 November 2010
Fund Project: 江苏省自然科学基金(BK2009721) (BK2009721)江苏科技大学博士人才(2008CL181)资助项目 (2008CL181)

Using 4,6-dichlorin-5-amino-pyrimidine as a starting material,a serials of 6-chlorin-8-alkyl-9-aryl-purine derivatives have been designed and synthesized via N-alkylation,condensation and chloridization.All synthesized compounds were confirmed by elemental analysis,MS and ¹H NMR techniques.The effects of catalyst on N-alkylation,the amounts of polyphosphoric acid(PPA) on condensation,the microwave heating process on chloridization were investigated.
- purine derivatives,
- N-alkylation,
- condensation,
- chloridization,
- synthesis
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