Home

Citation: ZHANG Yuehua, WANG Nanping, ZHANG Qiping, WANG Qingming, LU Tianhong. Fluorescence Spectroscopic Investigation of the Interaction between β-Cyclodextrin and Adriamycin[J]. Chinese Journal of Applied Chemistry, ;2011, 28(3): 343-348. doi: 10.3724/SP.J.1095.2011.00207 shu

Fluorescence Spectroscopic Investigation of the Interaction between β-Cyclodextrin and Adriamycin

1.
a School of Chemistry and Chemical Engineering, Nantong University, Nantong 226007;
2.
b School of Chemistry and Environmental Science, Nanjing Normal University, Nanjing

Corresponding author: WANG Nanping,
Received Date: 9 April 2010
Available Online: 5 August 2010
Fund Project: 国家自然科学基金(60571055) (60571055)江苏省自然科学基金(BK2009616)资助项目 (BK2009616)

The fluorescence spectroscopic technique has been used to demonstrate the formation of the inclusion complex of adriamycin (ADM) and β-cyclodextrin (β-CD). The effects of the reaction time, concentration and temperature on the inclusion reaction are investigated. The chemical stoichiometric ratio for the formation of the inclusion complexes is determined. The inclusion constant and thermodynamic parameters of the inclusion reactions at different temperatures are calculated. At 33℃ and pH=7.0, the inclusion constant, K is 2.98×10⁶ L/mol. The K value diminishes with the increase of temperature. Thus, the inclusion reaction is an enthalpy driving and spontaneous exothermic reaction. After ADM and β-CD form the inclusion complex, the fluorescence intensity is increased because β-CD can increase the natural fluorescence of ADM. Therefore, the fluorescence spectroscopic technique is an excellent technique for the investigation of the inclusion reaction of ADM and β-CD. The linear regression equation of the quantitative determination of ADM by β-CD sensitized fluorescence method is F=5.64×10⁸c+47.26, with a correlation coefficient of 0.9985. The detection limit is 6.30×10^-8 mol/L.
- β-cyclodextrin,
- adriamycin,
- inclusion,
- fluorescence spectroscopy
1. [1]
  Yahui HAN , Jinjin ZHAO , Ning REN , Jianjun ZHANG . Synthesis, crystal structure, thermal decomposition mechanism, and fluorescence properties of benzoic acid and 4-hydroxy-2, 2′: 6′, 2″-terpyridine lanthanide complexes. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 969-982. doi: 10.11862/CJIC.20240395
2. [2]
  Chun-Lin Sun , Yaole Jiang , Yu Chen , Rongjing Guo , Yongwen Shen , Xinping Hui , Baoxin Zhang , Xiaobo Pan . Construction, Performance Testing, and Practical Applications of a Home-Made Open Fluorescence Spectrometer. University Chemistry, 2024, 39(5): 287-295. doi: 10.3866/PKU.DXHX202311096
3. [3]
  Zhongxin YU , Wei SONG , Yang LIU , Yuxue DING , Fanhao MENG , Shuju WANG , Lixin YOU . Fluorescence sensing on chlortetracycline of a Zn-coordination polymer based on mixed ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2415-2421. doi: 10.11862/CJIC.20240304
4. [4]
  Peiling Li , Qing Feng , Hongling Yuan , Qin Wang . Live Interview Recording about the Penicillin Family. University Chemistry, 2024, 39(9): 122-127. doi: 10.3866/PKU.DXHX202311022
5. [5]
  Jiajie Li , Xiaocong Ma , Jufang Zheng , Qiang Wan , Xiaoshun Zhou , Yahao Wang . Recent Advances in In-Situ Raman Spectroscopy for Investigating Electrocatalytic Organic Reaction Mechanisms. University Chemistry, 2025, 40(4): 261-276. doi: 10.12461/PKU.DXHX202406117
6. [6]
  Tianlong Zhang , Rongling Zhang , Hongsheng Tang , Yan Li , Hua Li . Online Monitoring and Mechanistic Analysis of 3,5-diamino-1,2,4-triazole (DAT) Synthesis via Raman Spectroscopy: A Recommendation for a Comprehensive Instrumental Analysis Experiment. University Chemistry, 2024, 39(6): 303-311. doi: 10.3866/PKU.DXHX202312006
7. [7]
  Cuiping HE , Zhuxuan LI , Yuqing SUN , Jie LIU , Shicheng XU , Zhanchao WU . Ca²⁺ doping induced crystal phase transition and spectral regulation of Ba₃P₄O₁₃: Eu²⁺ phosphor. Chinese Journal of Inorganic Chemistry, 2025, 41(11): 2299-2306. doi: 10.11862/CJIC.20250074
8. [8]
  Jiarong Feng , Yejie Duan , Chu Chu , Dezhen Xie , Qiu'e Cao , Peng Liu . Preparation and Application of a Streptomycin Molecularly Imprinted Electrochemical Sensor: A Suggested Comprehensive Analytical Chemical Experiment. University Chemistry, 2024, 39(8): 295-305. doi: 10.3866/PKU.DXHX202401016
9. [9]
  Wentao Lin , Wenfeng Wang , Yaofeng Yuan , Chunfa Xu . Concerted Nucleophilic Aromatic Substitution Reactions. University Chemistry, 2024, 39(6): 226-230. doi: 10.3866/PKU.DXHX202310095
10. [10]
  Zhi Chai , Huashan Huang , Xukai Shi , Yujing Lan , Zhentao Yuan , Hong Yan . Wittig反应的立体选择性. University Chemistry, 2025, 40(8): 192-201. doi: 10.12461/PKU.DXHX202410046
11. [11]
  Hongyu Cheng , Ruiyao Wang , Xingwen Sun . Mechanistic Study of the Classic Hofmann Elimination Reaction. University Chemistry, 2025, 40(12): 187-191. doi: 10.12461/PKU.DXHX202510104
12. [12]
  Heng Zhang . Determination of All Rate Constants in the Enzyme Catalyzed Reactions Based on Michaelis-Menten Mechanism. University Chemistry, 2024, 39(4): 395-400. doi: 10.3866/PKU.DXHX202310047
13. [13]
  Yuting Zhang , Zhiqian Wang . Methods and Case Studies for In-Depth Learning of the Aldol Reaction Based on Its Reversible Nature. University Chemistry, 2024, 39(7): 377-380. doi: 10.3866/PKU.DXHX202311037
14. [14]
  Ruitong Zhang , Zhiqiang Zeng , Xiaoguang Zhang . Improvement of Ethyl Acetate Saponification Reaction and Iodine Clock Reaction Experiments. University Chemistry, 2024, 39(8): 197-203. doi: 10.3866/PKU.DXHX202312004
15. [15]
  Yan ZHAO , Xiaokang JIANG , Zhonghui LI , Jiaxu WANG , Hengwei ZHOU , Hai GUO . Preparation and fluorescence properties of Eu³⁺-doped CaLaGaO₄ red-emitting phosphors. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1861-1868. doi: 10.11862/CJIC.20240242
16. [16]
  Wenliang Wang , Weina Wang , Lixia Feng , Nan Wei , Sufan Wang , Tian Sheng , Tao Zhou . Proof and Interpretation of Severe Spectroscopic Selection Rules. University Chemistry, 2025, 40(3): 415-424. doi: 10.12461/PKU.DXHX202408063
17. [17]
  Yuan Chun , Lijun Yang , Jinyue Yang , Wei Gao . Ideological and Political Design of BZ Oscillatory Reaction Experiment. University Chemistry, 2024, 39(2): 72-76. doi: 10.3866/PKU.DXHX202308072
18. [18]
  Shiyan Cheng , Yonghong Ruan , Lei Gong , Yumei Lin . Research Advances in Friedel-Crafts Alkylation Reaction. University Chemistry, 2024, 39(10): 408-415. doi: 10.12461/PKU.DXHX202403024
19. [19]
  Huijuan Liao , Yulin Xiao , Dong Xue , Mingyu Yang , Jianyang Dong . Synthesis of 1-Benzyl Isoquinoline via the Minisci Reaction. University Chemistry, 2025, 40(7): 294-299. doi: 10.12461/PKU.DXHX202409092
20. [20]
  Bolin Sun , Jie Chen , Ling Zhou . 乙烯型卤代烃的亲核取代反应. University Chemistry, 2025, 40(8): 152-157. doi: 10.12461/PKU.DXHX202410032

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(566)
HTML views(51)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return