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Citation: LI Jing, ZHANG Meiyun, LI Quanmin. Spectrophotometric Determination of Cefotaxime Sodium with Potassium Ferricyanide[J]. Chinese Journal of Applied Chemistry, ;2011, 28(1): 88-93. doi: 10.3724/SP.J.1095.2011.00161 shu

Spectrophotometric Determination of Cefotaxime Sodium with Potassium Ferricyanide

1.
College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007

Corresponding author: LI Quanmin,
Received Date: 19 March 2010
Available Online: 5 June 2010
Fund Project: 河南省自然科学基金(0511020500)资助项目 (0511020500)

A spectrophotometric method has been set up to determine cefotaxime sodium using potassium ferricyanide as the spectroscopic probe reagent. With the presence of potassium ferricyanide, the degradation product of cefotaxime sodium can reduce Fe³⁺ to Fe²⁺ at pH 3.0, which facilitate the formation of soluble Prussian Blue (KFe^Ⅲ[Fe^Ⅱ(CN)₆]). The absorbance of soluble Prussian Blue is measured at its absorption maximum of 730 nm and the amount of cefotaxime sodium can be indirectly calculated. Under optimized conditions, a good linear relationship is obtained in the range of 0.040~24 mg/L of cefotaxime sodium. The linear regression equation is A=0.05088+0.2166ρ(mg/L) with linear correlation coefficient of 0.9986. The detection limit and relative standard deviation are 0.01 mg/L and 1.36%, respectively. Tthe apparent molar absorption coefficient of indirect determination of cefotaxime sodium is 2.3×10⁵ L/(mol·cm). This method has been successfully applied to the determination of cefotaxime sodium in pharmaceutical and serum samples.
- potassium ferricyanide,
- cefotaxime sodium,
- spectrophotometry
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